Reaction Details 
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Genome polyprotein
Ligand
BDBM50061546
Substrate
n/a
Meas. Tech.
ChEMBL_158975 (CHEMBL763742)
IC50
2800±n/a nM
Citation
Ogilvie, W; Bailey, M; Poupart, MA; Abraham, A; Bhavsar, A; Bonneau, P; Bordeleau, J; Bousquet, Y; Chabot, C; Duceppe, JS; Fazal, G; Goulet, S; Grand-Maître, C; Guse, I; Halmos, T; Lavallée, P; Leach, M; Malenfant, E; O'Meara, J; Plante, R; Plouffe, C; Poirier, M; Soucy, F; Yoakim, C; Déziel, R Peptidomimetic inhibitors of the human cytomegalovirus protease. J Med Chem 40:4113-35 (1998) [PubMed] ArticleMore Info.:
Target
Name:
Genome polyprotein
Synonyms:
Human rhinovirus A protease | Human rhinovirus B 3A protease
Type:
PROTEIN
Mol. Mass.:
44361.04
Organism:
Human rhinovirus B
Description:
ChEMBL_158953
Residue:
401
Sequence:
AFRPCNVNTKIGNAKCCPFVCGKAVTFKDRSTCSTYNLSSSLHHILEEDKRRRQVVDVMSAIFQGPISLDAPPPPAIADLLQSVRTPRVIKYCQIIMGHPAECQVERDLNIANSIIAIIANIISIAGIIFVIYKLFCSLQGPYSGEPKPKTKVPERRVVAQGPEEEFGRSILKNNTCVITTGNGKFTGLGIHDRILIIPTHADPGREVQVNGVHTKVLDSYDLYNRDGVKLEITVIQLDRNEKFRDIRKYIPETEDDYPECNLALSANQDEPTIIKVGDVVSYGNILLSGNQTARMLKYNYPTKSGYCGGVLYKIGQILGIHVGGNGRDGFSAMLLRSYFTGQIKVNKHATECGLPDIQTIHTPSKTKLQPSVFYDVFPGSKEPAVLTDNDPRLEVNFKEA
Inhibitor
Name:
BDBM50061546
Synonyms:
(S)-2-((S)-2-Acetylamino-3,3-dimethyl-butyrylamino)-N*4*,N*4*-dimethyl-N*1*-(3,3,3-trifluoro-1-methyl-2-oxo-propyl)-succinamide | CHEMBL133852
Type:
Small organic molecule
Emp. Form.:
C18H29F3N4O5
Mol. Mass.:
438.4419
SMILES:
CC(NC(=O)[C@H](CC(=O)N(C)C)NC(=O)[C@@H](NC(C)=O)C(C)(C)C)C(=O)C(F)(F)F
Structure:
