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Target
Serine/threonine-protein kinase 4
Ligand
BDBM50508990
Substrate
n/a
Meas. Tech.
ChEMBL_1837060 (CHEMBL4337193)
IC50
>10000±n/a nM
Citation
 Qiao, J; Lin, G; Xia, A; Xiang, Z; Chen, P; Zhang, G; Li, L; Yang, S Discovery of 1,8-disubstituted-[1,2,3]triazolo[4,5-c]quinoline derivatives as a new class of Hippo signaling pathway inhibitors. Bioorg Med Chem Lett 29:2595-2603 (2019) [PubMed]  Article
Target
Name:
Serine/threonine-protein kinase 4
Synonyms:
KRS2 | MST1 | STK4 | STK4_HUMAN | Serine/threonine-protein kinase 3/4 | Serine/threonine-protein kinase 4 (STK4) | Serine/threonine-protein kinase MST1
Type:
Enzyme
Mol. Mass.:
55611.40
Organism:
Homo sapiens (Human)
Description:
Q13043
Residue:
487
Sequence:
METVQLRNPPRRQLKKLDEDSLTKQPEEVFDVLEKLGEGSYGSVYKAIHKETGQIVAIKQVPVESDLQEIIKEISIMQQCDSPHVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLTEDEIATILQSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYNCVADIWSLGITAIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDNFTDFVKQCLVKSPEQRATATQLLQHPFVRSAKGVSILRDLINEAMDVKLKRQESQQREVDQDDEENSEEDEMDSGTMVRAVGDEMGTVRVASTMTDGANTMIEHDDTLPSQLGTMVINAEDEEEEGTMKRRDETMQPAKPSFLEYFEQKEKENQINSFGKSVPGPLKNSSDWKIPQDGDYEFLKSWTVEDLQKRLLALDPMMEQEIEEIRQKYQSKRQPILDAIEAKKRRQQNF
  
Inhibitor
Name:
BDBM50508990
Synonyms:
CHEMBL4472294
Type:
Small organic molecule
Emp. Form.:
C24H18N6
Mol. Mass.:
390.4399
SMILES:
C[C@@H](c1ccccc1)n1nnc2cnc3ccc(cc3c12)-c1cnc2[nH]ccc2c1 |r|
Structure:
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