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Target
Indoleamine 2,3-dioxygenase 1
Ligand
BDBM50235921
Substrate
n/a
Meas. Tech.
ChEMBL_1838980 (CHEMBL4339113)
IC50
14±n/a nM
Citation
 Steeneck, C; Kinzel, O; Anderhub, S; Hornberger, M; Pinto, S; Morschhaeuser, B; Braun, F; Kleymann, G; Hoffmann, T Discovery of Hydroxyamidine Based Inhibitors of IDO1 for Cancer Immunotherapy with Reduced Potential for Glucuronidation. ACS Med Chem Lett 11:179-187 (2020) [PubMed]  Article
Target
Name:
Indoleamine 2,3-dioxygenase 1
Synonyms:
I23O1_HUMAN | IDO | IDO-1 | IDO1 | INDO | Indoleamine 2,3-Dioxygenasae (IDO) | Indoleamine 2,3-dioxygenase | Indoleamine-pyrrole 2,3-dioxygenase
Type:
Enzyme
Mol. Mass.:
45330.80
Organism:
Homo sapiens (Human)
Description:
P14902
Residue:
403
Sequence:
MAHAMENSWTISKEYHIDEEVGFALPNPQENLPDFYNDWMFIAKHLPDLIESGQLRERVEKLNMLSIDHLTDHKSQRLARLVLGCITMAYVWGKGHGDVRKVLPRNIAVPYCQLSKKLELPPILVYADCVLANWKKKDPNKPLTYENMDVLFSFRDGDCSKGFFLVSLLVEIAAASAIKVIPTVFKAMQMQERDTLLKALLEIASCLEKALQVFHQIHDHVNPKAFFSVLRIYLSGWKGNPQLSDGLVYEGFWEDPKEFAGGSAGQSSVFQCFDVLLGIQQTAGGGHAAQFLQDMRRYMPPAHRNFLCSLESNPSVREFVLSKGDAGLREAYDACVKALVSLRSYHLQIVTKYILIPASQQPKENKTSEDPSKLEAKGTGGTDLMNFLKTVRSTTEKSLLKEG
  
Inhibitor
Name:
BDBM50235921
Synonyms:
CHEMBL584991
Type:
Small organic molecule
Emp. Form.:
C9H7ClFN5O2
Mol. Mass.:
271.636
SMILES:
Nc1nonc1\C(Nc1ccc(F)c(Cl)c1)=N\O
Structure:
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