Reaction Details 
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Serine/threonine-protein kinase pim-3
Ligand
BDBM50364776
Substrate
n/a
Meas. Tech.
ChEMBL_1840684 (CHEMBL4340983)
IC50
51±n/a nM
Citation
Martínez-González, S; Rodríguez-Arístegui, S; Gómez de la Oliva, CA; Hernández, AI; González Cantalapiedra, E; Varela, C; García, AB; Rabal, O; Oyarzabal, J; Bischoff, JR; Klett, J; Albarrán, MI; Cebriá, A; Ajenjo, N; García-Serelde, B; Gómez-Casero, E; Cuadrado-Urbano, M; Cebrián, D; Blanco-Aparicio, C; Pastor, J Discovery of novel triazolo[4,3-b]pyridazin-3-yl-quinoline derivatives as PIM inhibitors. Eur J Med Chem 168:87-109 (2019) [PubMed] ArticleMore Info.:
Target
Name:
Serine/threonine-protein kinase pim-3
Synonyms:
PIM3 | PIM3_HUMAN | Serine/threonine-protein kinase pim-3 (PIM3)
Type:
Protein
Mol. Mass.:
35888.19
Organism:
Homo sapiens (Human)
Description:
Q86V86
Residue:
326
Sequence:
MLLSKFGSLAHLCGPGGVDHLPVKILQPAKADKESFEKAYQVGAVLGSGGFGTVYAGSRIADGLPVAVKHVVKERVTEWGSLGGATVPLEVVLLRKVGAAGGARGVIRLLDWFERPDGFLLVLERPEPAQDLFDFITERGALDEPLARRFFAQVLAAVRHCHSCGVVHRDIKDENLLVDLRSGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSATVWSLGVLLYDMVCGDIPFEQDEEILRGRLLFRRRVSPECQQLIRWCLSLRPSERPSLDQIAAHPWMLGADGGVPESCDLRLCTLDPDDVASTTSSSESL
Inhibitor
Name:
BDBM50364776
Synonyms:
CHEMBL1952141 | CHEMBL1952329
Type:
Small organic molecule
Emp. Form.:
C20H22F3N5O
Mol. Mass.:
405.4168
SMILES:
CN1CCC(CNc2ccc3ncc(-c4cccc(OC(F)(F)F)c4)n3n2)CC1
Structure:
