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Target
Delta-type opioid receptor
Ligand
BDBM50269637
Substrate
n/a
Meas. Tech.
ChEMBL_1840722 (CHEMBL4341021)
EC50
95±n/a nM
Citation
 Pasquinucci, L; Turnaturi, R; Calò, G; Pappalardo, F; Ferrari, F; Russo, G; Arena, E; Montenegro, L; Chiechio, S; Prezzavento, O; Parenti, C (2S)-N-2-methoxy-2-phenylethyl-6,7-benzomorphan compound (2S-LP2): Discovery of a biased mu/delta opioid receptor agonist. Eur J Med Chem 168:189-198 (2019) [PubMed]  Article
Target
Name:
Delta-type opioid receptor
Synonyms:
D-OR-1 | DOR-1 | Delta opioid receptor | Delta-type opioid receptor (Delta) | OPIATE Delta | OPRD | OPRD1 | OPRD_HUMAN | OPRK1 | opioid receptor, delta 1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40382.98
Organism:
Homo sapiens (Human)
Description:
Competition binding assays were carried out using membrane preparations from transfected HN9.10 cells that constitutively expressed the delta opioid receptor.
Residue:
372
Sequence:
MEPAPSAGAELQPPLFANASDAYPSACPSAGANASGPPGARSASSLALAIAITALYSAVCAVGLLGNVLVMFGIVRYTKMKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELLCKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVGVPIMVMAVTRPRDGAVVCMLQFPSPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRLRSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDIDRRDPLVVAALHLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRKPCGRPDPSSFSRAREATARERVTACTPSDGPGGGAAA
  
Inhibitor
Name:
BDBM50269637
Synonyms:
CHEMBL4102093
Type:
Small organic molecule
Emp. Form.:
C23H29NO2
Mol. Mass.:
351.4819
SMILES:
[H][C@]12Cc3ccc(O)cc3[C@](C)(CCN1CC(OC)c1ccccc1)[C@H]2C |r,THB:15:14:25:9.3.2,8:9:25:14.12.13|
Structure:
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