Reaction Details  Report a problem with these data
Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM50065145
Substrate
n/a
Meas. Tech.
ChEMBL_200969 (CHEMBL802057)
Ki
41.8±n/a nM
Citation
 John, CS; Lim, BB; Vilner, BJ; Geyer, BC; Bowen, WD Substituted halogenated arylsulfonamides: a new class of sigma receptor binding tumor imaging agents. J Med Chem 41:2445-50 (1998) [PubMed]  Article
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
Aging-associated gene 8 protein | OPRS1 | SGMR1_HUMAN | SIG-1R | SIGMAR1 | SR-BP | SR31747-binding protein | SRBP | Sigma 1-type opioid receptor | Sigma opioid receptor | Sigma1R | hSigmaR1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
25124.85
Organism:
Homo sapiens (Human)
Description:
Q99720
Residue:
223
Sequence:
MQWAVGRRWAWAALLLAVAAVLTQVVWLWLGTQSFVFQREEIAQLARQYAGLDHELAFSRLIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSRGHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLAFALADTVFSTQDFLTLFYTLRSYARGLRLELTTYLFGQDP
  
Inhibitor
Name:
BDBM50065145
Synonyms:
3-Iodo-4-methoxy-N-(2-piperidin-1-yl-ethyl)-benzenesulfonamide | CHEMBL82081
Type:
Small organic molecule
Emp. Form.:
C14H21IN2O3S
Mol. Mass.:
424.298
SMILES:
COc1ccc(cc1I)S(=O)(=O)NCCN1CCCCC1
Structure:
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