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Target
C-C chemokine receptor type 8
Ligand
BDBM50511108
Substrate
n/a
Meas. Tech.
ChEMBL_1843807 (CHEMBL4344234)
IC50
5200±n/a nM
Citation
 Norwood, VM; Brice-Tutt, AC; Eans, SO; Stacy, HM; Shi, G; Ratnayake, R; Rocca, JR; Abboud, KA; Li, C; Luesch, H; McLaughlin, JP; Huigens, RW Preventing Morphine-Seeking Behavior through the Re-Engineering of Vincamine's Biological Activity. J Med Chem 63:5119-5138 (2020) [PubMed]  Article
Target
Name:
C-C chemokine receptor type 8
Synonyms:
CCR8 | CCR8_HUMAN | CKRL1 | CMKBR8 | CMKBRL2
Type:
PROTEIN
Mol. Mass.:
40855.53
Organism:
Homo sapiens (Human)
Description:
ChEMBL_454278
Residue:
355
Sequence:
MDYTLDLSVTTVTDYYYPDIFSSPCDAELIQTNGKLLLAVFYCLLFVFSLLGNSLVILVLVVCKKLRSITDVYLLNLALSDLLFVFSFPFQTYYLLDQWVFGTVMCKVVSGFYYIGFYSSMFFITLMSVDRYLAVVHAVYALKVRTIRMGTTLCLAVWLTAIMATIPLLVFYQVASEDGVLQCYSFYNQQTLKWKIFTNFKMNILGLLIPFTIFMFCYIKILHQLKRCQNHNKTKAIRLVLIVVIASLLFWVPFNVVLFLTSLHSMHILDGCSISQQLTYATHVTEIISFTHCCVNPVIYAFVGEKFKKHLSEIFQKSCSQIFNYLGRQMPRESCEKSSSCQQHSSRSSSVDYIL
  
Inhibitor
Name:
BDBM50511108
Synonyms:
CHEMBL4558185
Type:
Small organic molecule
Emp. Form.:
C29H29BrN4O3
Mol. Mass.:
561.47
SMILES:
[H][C@]12N(CCC[C@@]1(CC)C=C(C(=O)OC)n1c2c(CCNC(=O)c2ccc(Br)cc2)c2ccccc12)C#N |r,t:10|
Structure:
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