Reaction Details  Report a problem with these data
Target
fMet-Leu-Phe receptor
Ligand
BDBM50511108
Substrate
n/a
Meas. Tech.
ChEMBL_1843808 (CHEMBL4344235)
IC50
1080±n/a nM
Citation
 Norwood, VM; Brice-Tutt, AC; Eans, SO; Stacy, HM; Shi, G; Ratnayake, R; Rocca, JR; Abboud, KA; Li, C; Luesch, H; McLaughlin, JP; Huigens, RW Preventing Morphine-Seeking Behavior through the Re-Engineering of Vincamine's Biological Activity. J Med Chem 63:5119-5138 (2020) [PubMed]  Article
Target
Name:
fMet-Leu-Phe receptor
Synonyms:
FPR | FPR1 | FPR1_HUMAN | Formyl peptide Receptor | N-formyl peptide receptor 1 | N-formylpeptide chemoattractant receptor | fMLP receptor | fMet-Leu-Phe receptor | formyl peptide receptor 1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
38456.14
Organism:
Homo sapiens (Human)
Description:
gi_4503779
Residue:
350
Sequence:
METNSSLPTNISGGTPAVSAGYLFLDIITYLVFAVTFVLGVLGNGLVIWVAGFRMTHTVTTISYLNLAVADFCFTSTLPFFMVRKAMGGHWPFGWFLCKFVFTIVDINLFGSVFLIALIALDRCVCVLHPVWTQNHRTVSLAKKVIIGPWVMALLLTLPVIIRVTTVPGKTGTVACTFNFSPWTNDPKERINVAVAMLTVRGIIRFIIGFSAPMSIVAVSYGLIATKIHKQGLIKSSRPLRVLSFVAAAFFLCWSPYQVVALIATVRIRELLQGMYKEIGIAVDVTSALAFFNSCLNPMLYVFMGQDFRERLIHALPASLERALTEDSTQTSDTATNSTLPSAEVELQAK
  
Inhibitor
Name:
BDBM50511108
Synonyms:
CHEMBL4558185
Type:
Small organic molecule
Emp. Form.:
C29H29BrN4O3
Mol. Mass.:
561.47
SMILES:
[H][C@]12N(CCC[C@@]1(CC)C=C(C(=O)OC)n1c2c(CCNC(=O)c2ccc(Br)cc2)c2ccccc12)C#N |r,t:10|
Structure:
Search PDB for entries with ligand similarity: