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Target
Receptor-interacting serine/threonine-protein kinase 3
Ligand
BDBM50511306
Substrate
n/a
Meas. Tech.
ChEMBL_1844453 (CHEMBL4344880)
IC50
0.300000±n/a nM
Citation
 Hart, AC; Abell, L; Guo, J; Mertzman, ME; Padmanabha, R; Macor, JE; Chaudhry, C; Lu, H; O'Malley, K; Shaw, PJ; Weigelt, C; Pokross, M; Kish, K; Kim, KS; Cornelius, L; Douglas, AE; Calambur, D; Zhang, P; Carpenter, B; Pitts, WJ Identification of RIPK3 Type II Inhibitors Using High-Throughput Mechanistic Studies in Hit Triage. ACS Med Chem Lett 11:266-271 (2020) [PubMed]  Article
Target
Name:
Receptor-interacting serine/threonine-protein kinase 3
Synonyms:
RIP-3 | RIP-like protein kinase 3 | RIP3 | RIPK3 | RIPK3_HUMAN | Receptor-interacting protein 3
Type:
PROTEIN
Mol. Mass.:
56886.12
Organism:
Homo sapiens (Human)
Description:
ChEMBL_881455
Residue:
518
Sequence:
MSCVKLWPSGAPAPLVSIEELENQELVGKGGFGTVFRAQHRKWGYDVAVKIVNSKAISREVKAMASLDNEFVLRLEGVIEKVNWDQDPKPALVTKFMENGSLSGLLQSQCPRPWPLLCRLLKEVVLGMFYLHDQNPVLLHRDLKPSNVLLDPELHVKLADFGLSTFQGGSQSGTGSGEPGGTLGYLAPELFVNVNRKASTASDVYSFGILMWAVLAGREVELPTEPSLVYEAVCNRQNRPSLAELPQAGPETPGLEGLKELMQLCWSSEPKDRPSFQECLPKTDEVFQMVENNMNAAVSTVKDFLSQLRSSNRRFSIPESGQGGTEMDGFRRTIENQHSRNDVMVSEWLNKLNLEEPPSSVPKKCPSLTKRSRAQEEQVPQAWTAGTSSDSMAQPPQTPETSTFRNQMPSPTSTGTPSPGPRGNQGAERQGMNWSCRTPEPNPVTGRPLVNIYNCSGVQVGDNNYLTMQQTTALPTWGLAPSGKGRGLQHPPPVGSQEGPKDPEAWSRPQGWYNHSGK
  
Inhibitor
Name:
BDBM50511306
Synonyms:
CHEMBL4470115
Type:
Small organic molecule
Emp. Form.:
C30H20F2N6O3
Mol. Mass.:
550.515
SMILES:
Nc1ccc(nc1)C#Cc1c(N)nccc1Oc1ccc(NC(=O)c2cccn(-c3ccc(F)cc3)c2=O)cc1F
Structure:
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