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Target
Protein arginine N-methyltransferase 6
Ligand
BDBM50511921
Substrate
n/a
Meas. Tech.
ChEMBL_1846151 (CHEMBL4346578)
IC50
28±n/a nM
Citation
 Shen, Y; Li, F; Szewczyk, MM; Halabelian, L; Park, KS; Chau, I; Dong, A; Zeng, H; Chen, H; Meng, F; Barsyte-Lovejoy, D; Arrowsmith, CH; Brown, PJ; Liu, J; Vedadi, M; Jin, J Discovery of a First-in-Class Protein Arginine Methyltransferase 6 (PRMT6) Covalent Inhibitor. J Med Chem 63:5477-5487 (2020) [PubMed]  Article
Target
Name:
Protein arginine N-methyltransferase 6
Synonyms:
ANM6_HUMAN | HRMT1L6 | Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 6 | Histone-arginine N-methyltransferase PRMT6 | PRMT6 | Protein arginine methyltransferase 6 (PRMT6)
Type:
Protein
Mol. Mass.:
41928.48
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
375
Sequence:
MSQPKKRKLESGGGGEGGEGTEEEDGAEREAALERPRRTKRERDQLYYECYSDVSVHEEMIADRVRTDAYRLGILRNWAALRGKTVLDVGAGTGILSIFCAQAGARRVYAVEASAIWQQAREVVRFNGLEDRVHVLPGPVETVELPEQVDAIVSEWMGYGLLHESMLSSVLHARTKWLKEGGLLLPASAELFIAPISDQMLEWRLGFWSQVKQHYGVDMSCLEGFATRCLMGHSEIVVQGLSGEDVLARPQRFAQLELSRAGLEQELEAGVGGRFRCSCYGSAPMHGFAIWFQVTFPGGESEKPLVLSTSPFHPATHWKQALLYLNEPVQVEQDTDVSGEITLLPSRDNPRRLRVLLRYKVGDQEEKTKDFAMED
  
Inhibitor
Name:
BDBM50511921
Synonyms:
CHEMBL4544587
Type:
Small organic molecule
Emp. Form.:
C17H24N4O
Mol. Mass.:
300.3987
SMILES:
CCC(=O)Nc1cccc(c1)-c1c[nH]cc1CN(C)CCN
Structure:
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