Reaction Details  Report a problem with these data
Target
Cannabinoid receptor 2
Ligand
BDBM50514054
Substrate
n/a
Meas. Tech.
ChEMBL_1855547 (CHEMBL4356276)
Ki
28700±n/a nM
Citation
 Scheiner, M; Dolles, D; Gunesch, S; Hoffmann, M; Nabissi, M; Marinelli, O; Naldi, M; Bartolini, M; Petralla, S; Poeta, E; Monti, B; Falkeis, C; Vieth, M; Hübner, H; Gmeiner, P; Maitra, R; Maurice, T; Decker, M Dual-Acting Cholinesterase-Human Cannabinoid Receptor 2 Ligands Show Pronounced Neuroprotection in Vitro and Overadditive and Disease-Modifying Neuroprotective Effects in Vivo. J Med Chem 62:9078-9102 (2019) [PubMed]  Article
Target
Name:
Cannabinoid receptor 2
Synonyms:
CANNABINOID CB2 | CB-2 | CB2 | CB2A | CB2B | CNR2 | CNR2_HUMAN | CX5 | Cannabinoid CB2 receptor | Cannabinoid receptor 2 (CB2) | Cannabinoid receptor 2 (CB2R) | hCB2
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
39690.94
Organism:
Homo sapiens (Human)
Description:
P34972
Residue:
360
Sequence:
MEECWVTEIANGSKDGLDSNPMKDYMILSGPQKTAVAVLCTLLGLLSALENVAVLYLILSSHQLRRKPSYLFIGSLAGADFLASVVFACSFVNFHVFHGVDSKAVFLLKIGSVTMTFTASVGSLLLTAIDRYLCLRYPPSYKALLTRGRALVTLGIMWVLSALVSYLPLMGWTCCPRPCSELFPLIPNDYLLSWLLFIAFLFSGIIYTYGHVLWKAHQHVASLSGHQDRQVPGMARMRLDVRLAKTLGLVLAVLLICWFPVLALMAHSLATTLSDQVKKAFAFCSMLCLINSMVNPVIYALRSGEIRSSAHHCLAHWKKCVRGLGSEAKEEAPRSSVTETEADGKITPWPDSRDLDLSDC
  
Inhibitor
Name:
BDBM50514054
Synonyms:
CHEMBL4456433
Type:
Small organic molecule
Emp. Form.:
C40H49N5O4
Mol. Mass.:
663.8482
SMILES:
CCOc1ccc(Cc2nc3cc(ccc3n2CCOCCOCCNc2c3CCCCc3nc3ccccc23)C(=O)N(CC)CC)cc1
Structure:
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