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Target
Interstitial collagenase
Ligand
BDBM50069602
Substrate
n/a
Meas. Tech.
ChEBML_70456
IC50
>10000±n/a nM
Citation
 Bailey, S; Bolognese, B; Buckle, DR; Faller, A; Jackson, S; Louis-Flamberg, P; McCord, M; Mayer, RJ; Marshall, LA; Smith, DG Selective inhibition of low affinity IgE receptor (CD23) processing. Bioorg Med Chem Lett 8:29-34 (1999) [PubMed]
Target
Name:
Interstitial collagenase
Synonyms:
CLG | Fibroblast collagenase | MMP1 | MMP1_HUMAN | Matrix metalloproteinase-1 | Matrix metalloproteinase-1 (MMP-1)
Type:
Enzyme
Mol. Mass.:
54010.26
Organism:
Homo sapiens (Human)
Description:
P03956
Residue:
469
Sequence:
MHSFPPLLLLLFWGVVSHSFPATLETQEQDVDLVQKYLEKYYNLKNDGRQVEKRRNSGPVVEKLKQMQEFFGLKVTGKPDAETLKVMKQPRCGVPDVAQFVLTEGNPRWEQTHLTYRIENYTPDLPRADVDHAIEKAFQLWSNVTPLTFTKVSEGQADIMISFVRGDHRDNSPFDGPGGNLAHAFQPGPGIGGDAHFDEDERWTNNFREYNLHRVAAHELGHSLGLSHSTDIGALMYPSYTFSGDVQLAQDDIDGIQAIYGRSQNPVQPIGPQTPKACDSKLTFDAITTIRGEVMFFKDRFYMRTNPFYPEVELNFISVFWPQLPNGLEAAYEFADRDEVRFFKGNKYWAVQGQNVLHGYPKDIYSSFGFPRTVKHIDAALSEENTGKTYFFVANKYWRYDEYKRSMDPGYPKMIAHDFPGIGHKVDAVFMKDGFFYFFHGTRQYKFDPKTKRILTLQKANSWFNCRKN
  
Inhibitor
Name:
BDBM50069602
Synonyms:
CHEMBL440712 | Thioacetic acid S-[(2S,3R)-3-((S)-1-carbamoyl-2-phenyl-ethylcarbamoyl)-2-hydroxycarbamoyl-5-methyl-hexyl] ester
Type:
Small organic molecule
Emp. Form.:
C20H29N3O5S
Mol. Mass.:
423.526
SMILES:
CC(C)C[C@H]([C@H](CSC(C)=O)C(=O)NO)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Structure:
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