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Target
Signal transducer and activator of transcription 5B
Ligand
BDBM50514413
Substrate
n/a
Meas. Tech.
ChEMBL_1856596 (CHEMBL4357325)
IC50
76000±n/a nM
Citation
 Bosc, D; Camberlein, V; Gealageas, R; Castillo-Aguilera, O; Deprez, B; Deprez-Poulain, R Kinetic Target-Guided Synthesis: Reaching the Age of Maturity. J Med Chem 63:3817-3833 (2020) [PubMed]  Article
Target
Name:
Signal transducer and activator of transcription 5B
Synonyms:
STA5B_MOUSE | Signal transducer and activator of transcription 5B | Stat5b
Type:
PROTEIN
Mol. Mass.:
89994.52
Organism:
Mus musculus
Description:
ChEMBL_118975
Residue:
786
Sequence:
MAMWIQAQQLQGDALHQMQALYGQHFPIEVRHYLSQWIESQAWDSIDLDNPQENIKATQLLEGLVQELQKKAEHQVGEDGFLLKIKLGHYATQLQSTYDRCPMELVRCIRHILYNEQRLVREANNGSSPAGSLADAMSQKHLQINQTFEELRLITQDTENELKKLQQTQEYFIIQYQESLRIQAQFAQLGQLNPQERMSRETALQQKQVSLETWLQREAQTLQQYRVELAEKHQKTLQLLRKQQTIILDDELIQWKRRQQLAGNGGPPEGSLDVLQSWCEKLAEIIWQNRQQIRRAEHLCQQLPIPGPVEEMLAEVNATITDIISALVTSTFIIEKQPPQVLKTQTKFAATVRLLVGGKLNVHMNPPQVKATIISEQQAKSLLKNENTRNDYSGEILNNCCVMEYHQATGTLSAHFRNMSLKRIKRSDRRGAESVTEEKFTILFDSQFSVGGNELVFQVKTLSLPVVVIVHGSQDNNATATVLWDNAFAEPGRVPFAVPDKVLWPQLCEALNMKFKAEVQSNRGLTKENLVFLAQKLFNISSNHLEDYNSMSVSWSQFNRENLPGRNYTFWQWFDGVMEVLKKHLKPHWNDGAILGFVNKQQAHDLLINKPDGTFLLRFSDSEIGGITIAWKFDSQERMFWNLMPFTTRDFSIRSLADRLGDLNYLIYVFPDRPKDEVYSKYYTPVPCEPATAKAADGYVKPQIKQVVPEFANASTDAGSGATYMDQAPSPVVCPQAHYNMYPPNPDSVLDTDGDFDLEDTMDVARRVEELLGRPMDSQWIPHAQS
  
Inhibitor
Name:
BDBM50514413
Synonyms:
CHEMBL4555061
Type:
Small organic molecule
Emp. Form.:
C12H11N7O3
Mol. Mass.:
301.2608
SMILES:
OC(=O)c1nonc1NCn1nnnc1Cc1ccccc1
Structure:
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