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Target
Histamine H3 receptor
Ligand
BDBM50071494
Substrate
n/a
Meas. Tech.
ChEBML_85851
Ki
140±n/a nM
Citation
 Aslanian, R; Brown, JE; Shih, NY; wa Mutahi, M; Green, MJ; She, S; Del Prado, M; West, R; Hey, J 4-[(1H-imidazol-4-yl) methyl] benzamidines and benzylamidines: novel antagonists of the histamine H3 receptor. Bioorg Med Chem Lett 8:2263-8 (1999) [PubMed]
Target
Name:
Histamine H3 receptor
Synonyms:
HISTAMINE H3 | HRH3 | HRH3_CAVPO | Histamine H3 receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
48753.61
Organism:
GUINEA PIG
Description:
HISTAMINE H3 HRH3 GUINEA PIG::Q9JI35
Residue:
445
Sequence:
MERAPPDGLMNASGALAGEAAAAAGGARTFSAAWTAVLAALMALLIVATVLGNALVMLAFVADSSLRTQNNFFLLNLAISDFLVGVFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCTSSVFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMVLVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGGAREAGPDPLPEAQSSPPQPPPGCWGCWPKGQGESMPLHRYGVGEAGPGAEAGEAALGGGSGAAASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSITQRFRLSRDKKVAKSLAIIVSIFGLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHYSFRRAFTKLLCPQKLKVQPHSSLEHCWK
  
Inhibitor
Name:
BDBM50071494
Synonyms:
4-(1H-Imidazol-4-ylmethyl)-N-(4-trifluoromethyl-benzyl)-benzamidine | CHEMBL75332
Type:
Small organic molecule
Emp. Form.:
C19H17F3N4
Mol. Mass.:
358.3603
SMILES:
NC(=NCc1ccc(cc1)C(F)(F)F)c1ccc(Cc2cnc[nH]2)cc1 |w:2.2|
Structure:
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