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Target
Neutrophil elastase
Ligand
BDBM50516762
Substrate
n/a
Meas. Tech.
ChEMBL_1866701 (CHEMBL4367676)
IC50
2700±n/a nM
Citation
 Fernandes, GFS; Denny, WA; Dos Santos, JL Boron in drug design: Recent advances in the development of new therapeutic agents. Eur J Med Chem 179:791-804 (2019) [PubMed]  Article
Target
Name:
Neutrophil elastase
Synonyms:
Bone marrow serine protease | Chymotrypsin | Coagulation factor X | ELA2 | ELANE | ELNE_HUMAN | Elastase | Elastase-2 | HLE | Human leukocyte elastase | Leukocyte elastase | Leukocyte elastase (HLE) | Medullasin | Neutrophil elastase | Neutrophil elastase (HNE) | Neutrophil elastase (NE) | PMN elastase | Thrombin | Trypsin
Type:
Enzyme
Mol. Mass.:
28532.38
Organism:
Homo sapiens (Human)
Description:
P08246
Residue:
267
Sequence:
MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLIAPNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVILQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSLCRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVNWIDSIIQRSEDNPCPHPRDPDPASRTH
  
Inhibitor
Name:
BDBM50516762
Synonyms:
CHEMBL4474485
Type:
Small organic molecule
Emp. Form.:
C12H11BN2OS
Mol. Mass.:
242.105
SMILES:
OB1N(Cc2ccccc2)N=Cc2ccsc12 |c:11|
Structure:
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