Reaction Details  Report a problem with these data
Target
Dihydrofolate reductase
Ligand
BDBM50516935
Substrate
n/a
Meas. Tech.
ChEMBL_1867173 (CHEMBL4368148)
IC50
150000±n/a nM
Citation
 Garg, V; Maurya, RK; Thanikachalam, PV; Bansal, G; Monga, V An insight into the medicinal perspective of synthetic analogs of indole: A review. Eur J Med Chem 180:562-612 (2019) [PubMed]  Article
Target
Name:
Dihydrofolate reductase
Synonyms:
DYR_MYCTU | dfrA | folA
Type:
PROTEIN
Mol. Mass.:
17872.62
Organism:
Mycobacterium tuberculosis
Description:
ChEMBL_102873
Residue:
161
Sequence:
MTMVGLIWAQATSGVIGRGGDIPWRLPEDQAHFREITMGHTIVMGRRTWDSLPAKVRPLPGRRNVVLSRQADFMASGAEVVGSLEEALTSPETWVIGGGQVYALALPYATRCEVTEVDIGLPREAGDALAPVLDETWRGETGEWRFSRSGLRYRLYSYHRS
  
Inhibitor
Name:
BDBM50516935
Synonyms:
CHEMBL4526073
Type:
Small organic molecule
Emp. Form.:
C22H23NO4
Mol. Mass.:
365.4223
SMILES:
CC(=O)c1c(C)n(Cc2ccccc2)c2ccc(OCCCC(O)=O)cc12
Structure:
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