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Target
Estrogen receptor beta
Ligand
BDBM50517927
Substrate
n/a
Meas. Tech.
ChEMBL_1870078 (CHEMBL4371245)
EC50
1400±n/a nM
Citation
 Hanson, AM; Perera, KLIS; Kim, J; Pandey, RK; Sweeney, N; Lu, X; Imhoff, A; Mackinnon, AC; Wargolet, AJ; Van Hart, RM; Frick, KM; Donaldson, WA; Sem, DS A-C Estrogens as Potent and Selective Estrogen Receptor-Beta Agonists (SERBAs) to Enhance Memory Consolidation under Low-Estrogen Conditions. J Med Chem 61:4720-4738 (2018) [PubMed]  Article
Target
Name:
Estrogen receptor beta
Synonyms:
ER-beta | ESR2 | ESR2_HUMAN | ESTRB | Estradiol receptor beta (ERβ) | Estrogen receptor | Estrogen receptor (ER beta) | Estrogen receptor beta | Estrogen receptor beta (ER beta) | Estrogen receptor beta (ER) | NR3A2 | Nuclear receptor subfamily 3 group A member 2 | estrogen beta
Type:
Protein
Mol. Mass.:
59238.43
Organism:
Homo sapiens (Human)
Description:
Q92731
Residue:
530
Sequence:
MDIKNSPSSLNSPSSYNCSQSILPLEHGSIYIPSSYVDSHHEYPAMTFYSPAVMNYSIPSNVTNLEGGPGRQTTSPNVLWPTPGHLSPLVVHRQLSHLYAEPQKSPWCEARSLEHTLPVNRETLKRKVSGNRCASPVTGPGSKRDAHFCAVCSDYASGYHYGVWSCEGCKAFFKRSIQGHNDYICPATNQCTIDKNRRKSCQACRLRKCYEVGMVKCGSRRERCGYRLVRRQRSADEQLHCAGKAKRSGGHAPRVRELLLDALSPEQLVLTLLEAEPPHVLISRPSAPFTEASMMMSLTKLADKELVHMISWAKKIPGFVELSLFDQVRLLESCWMEVLMMGLMWRSIDHPGKLIFAPDLVLDRDEGKCVEGILEIFDMLLATTSRFRELKLQHKEYLCVKAMILLNSSMYPLVTATQDADSSRKLAHLLNAVTDALVWVIAKSGISSQQQSMRLANLLMLLSHVRHASNKGMEHLLNMKCKNVVPVYDLLLEMLNAHVLRGCKSSITGSECSPAEDSKSKEGSQNPQSQ
  
Inhibitor
Name:
BDBM50517927
Synonyms:
CHEMBL4472153
Type:
Small organic molecule
Emp. Form.:
C16H20O3
Mol. Mass.:
260.3282
SMILES:
CCOC(=O)C=C1CCC(CC1)c1ccc(O)cc1 |(78.96,-27.5,;77.42,-27.5,;76.65,-26.16,;75.11,-26.16,;74.35,-24.82,;74.34,-27.49,;72.8,-27.48,;72.02,-28.81,;70.49,-28.81,;69.72,-27.47,;70.48,-26.14,;72.03,-26.14,;68.18,-27.47,;67.41,-26.13,;65.87,-26.13,;65.1,-27.47,;63.56,-27.47,;65.88,-28.8,;67.42,-28.8,)|
Structure:
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