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Target
Estrogen receptor beta
Ligand
BDBM50517932
Substrate
n/a
Meas. Tech.
ChEMBL_1870078 (CHEMBL4371245)
EC50
2700±n/a nM
Citation
 Hanson, AM; Perera, KLIS; Kim, J; Pandey, RK; Sweeney, N; Lu, X; Imhoff, A; Mackinnon, AC; Wargolet, AJ; Van Hart, RM; Frick, KM; Donaldson, WA; Sem, DS A-C Estrogens as Potent and Selective Estrogen Receptor-Beta Agonists (SERBAs) to Enhance Memory Consolidation under Low-Estrogen Conditions. J Med Chem 61:4720-4738 (2018) [PubMed]  Article
Target
Name:
Estrogen receptor beta
Synonyms:
ER-beta | ESR2 | ESR2_HUMAN | ESTRB | Estradiol receptor beta (ERβ) | Estrogen receptor | Estrogen receptor (ER beta) | Estrogen receptor beta | Estrogen receptor beta (ER beta) | Estrogen receptor beta (ER) | NR3A2 | Nuclear receptor subfamily 3 group A member 2 | estrogen beta
Type:
Protein
Mol. Mass.:
59238.43
Organism:
Homo sapiens (Human)
Description:
Q92731
Residue:
530
Sequence:
MDIKNSPSSLNSPSSYNCSQSILPLEHGSIYIPSSYVDSHHEYPAMTFYSPAVMNYSIPSNVTNLEGGPGRQTTSPNVLWPTPGHLSPLVVHRQLSHLYAEPQKSPWCEARSLEHTLPVNRETLKRKVSGNRCASPVTGPGSKRDAHFCAVCSDYASGYHYGVWSCEGCKAFFKRSIQGHNDYICPATNQCTIDKNRRKSCQACRLRKCYEVGMVKCGSRRERCGYRLVRRQRSADEQLHCAGKAKRSGGHAPRVRELLLDALSPEQLVLTLLEAEPPHVLISRPSAPFTEASMMMSLTKLADKELVHMISWAKKIPGFVELSLFDQVRLLESCWMEVLMMGLMWRSIDHPGKLIFAPDLVLDRDEGKCVEGILEIFDMLLATTSRFRELKLQHKEYLCVKAMILLNSSMYPLVTATQDADSSRKLAHLLNAVTDALVWVIAKSGISSQQQSMRLANLLMLLSHVRHASNKGMEHLLNMKCKNVVPVYDLLLEMLNAHVLRGCKSSITGSECSPAEDSKSKEGSQNPQSQ
  
Inhibitor
Name:
BDBM50517932
Synonyms:
CHEMBL4459147
Type:
Small organic molecule
Emp. Form.:
C13H18O3
Mol. Mass.:
222.2802
SMILES:
OC[C@]1(O)CC[C@@H](CC1)c1ccc(O)cc1 |r,wU:6.9,2.1,(73.8,-15.59,;73.81,-17.13,;72.48,-17.9,;73.82,-18.67,;71.72,-16.57,;70.17,-16.56,;69.41,-17.9,;70.18,-19.23,;71.71,-19.24,;67.87,-17.9,;67.1,-16.56,;65.56,-16.56,;64.79,-17.89,;63.25,-17.89,;65.57,-19.23,;67.11,-19.22,)|
Structure:
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