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Target
Estrogen receptor beta
Ligand
BDBM50517936
Substrate
n/a
Meas. Tech.
ChEMBL_1870077 (CHEMBL4371244)
EC50
>10000±n/a nM
Citation
 Hanson, AM; Perera, KLIS; Kim, J; Pandey, RK; Sweeney, N; Lu, X; Imhoff, A; Mackinnon, AC; Wargolet, AJ; Van Hart, RM; Frick, KM; Donaldson, WA; Sem, DS A-C Estrogens as Potent and Selective Estrogen Receptor-Beta Agonists (SERBAs) to Enhance Memory Consolidation under Low-Estrogen Conditions. J Med Chem 61:4720-4738 (2018) [PubMed]  Article
Target
Name:
Estrogen receptor beta
Synonyms:
ER-beta | ESR2 | ESR2_HUMAN | ESTRB | Estradiol receptor beta (ERβ) | Estrogen receptor | Estrogen receptor (ER beta) | Estrogen receptor beta | Estrogen receptor beta (ER beta) | Estrogen receptor beta (ER) | NR3A2 | Nuclear receptor subfamily 3 group A member 2 | estrogen beta
Type:
Protein
Mol. Mass.:
59238.43
Organism:
Homo sapiens (Human)
Description:
Q92731
Residue:
530
Sequence:
MDIKNSPSSLNSPSSYNCSQSILPLEHGSIYIPSSYVDSHHEYPAMTFYSPAVMNYSIPSNVTNLEGGPGRQTTSPNVLWPTPGHLSPLVVHRQLSHLYAEPQKSPWCEARSLEHTLPVNRETLKRKVSGNRCASPVTGPGSKRDAHFCAVCSDYASGYHYGVWSCEGCKAFFKRSIQGHNDYICPATNQCTIDKNRRKSCQACRLRKCYEVGMVKCGSRRERCGYRLVRRQRSADEQLHCAGKAKRSGGHAPRVRELLLDALSPEQLVLTLLEAEPPHVLISRPSAPFTEASMMMSLTKLADKELVHMISWAKKIPGFVELSLFDQVRLLESCWMEVLMMGLMWRSIDHPGKLIFAPDLVLDRDEGKCVEGILEIFDMLLATTSRFRELKLQHKEYLCVKAMILLNSSMYPLVTATQDADSSRKLAHLLNAVTDALVWVIAKSGISSQQQSMRLANLLMLLSHVRHASNKGMEHLLNMKCKNVVPVYDLLLEMLNAHVLRGCKSSITGSECSPAEDSKSKEGSQNPQSQ
  
Inhibitor
Name:
BDBM50517936
Synonyms:
CHEMBL4453541
Type:
Small organic molecule
Emp. Form.:
C13H18O
Mol. Mass.:
190.2814
SMILES:
CC1CCC(CC1)c1ccc(O)cc1 |(29.12,-19.6,;27.58,-19.59,;26.8,-20.92,;25.27,-20.92,;24.5,-19.58,;25.27,-18.25,;26.81,-18.26,;22.96,-19.58,;22.19,-18.25,;20.65,-18.25,;19.88,-19.58,;18.34,-19.58,;20.66,-20.92,;22.2,-20.91,)|
Structure:
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