Target

Ligand

Substrate

Meas. Tech.

ChEMBL_1872177 (CHEMBL4373344)

Citation

 Poslusney, MS; Salovich, JM; Wood, MR; Melancon, BJ; Bollinger, KA; Luscombe, VB; Rodriguez, AL; Engers, DW; Bridges, TM; Niswender, CM; Conn, PJ; Lindsley, CW Novel M Bioorg Med Chem Lett 29:362-366 (2019) [PubMed]  Article

More Info.:

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Name:

Muscarinic acetylcholine receptor M4

Synonyms:

ACM4_HUMAN | CHRM4 | Cholinergic, muscarinic M4 | Muscarinic acetylcholine receptor | Muscarinic acetylcholine receptor M2 and M4

Type:

Enzyme Catalytic Domain

Mol. Mass.:

53079.31

Organism:

Homo sapiens (Human)

Description:

Cholinergic, muscarinic M4 CHRM4 HUMAN M3::P08173

Residue:

479

Sequence:

MANFTPVNGSSGNQSVRLVTSSSHNRYETVEMVFIATVTGSLSLVTVVGNILVMLSIKVNRQLQTVNNYFLFSLACADLIIGAFSMNLYTVYIIKGYWPLGAVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPARRTTKMAGLMIAAAWVLSFVLWAPAILFWQFVVGKRTVPDNQCFIQFLSNPAVTFGTAIAAFYLPVVIMTVLYIHISLASRSRVHKHRPEGPKEKKAKTLAFLKSPLMKQSVKKPPPGEAAREELRNGKLEEAPPPALPPPPRPVADKDTSNESSSGSATQNTKERPATELSTTEATTPAMPAPPLQPRALNPASRWSKIQIVTKQTGNECVTAIEIVPATPAGMRPAANVARKFASIARNQVRKKRQMAARERKVTRTIFAILLAFILTWTPYNVMVLVNTFCQSCIPDTVWSIGYWLCYVNSTINPACYALCNATFKKTFRHLLLCQYRNIGTAR

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Name:

BDBM50518704

Synonyms:

CHEMBL4556846

Type:

Small organic molecule

Emp. Form.:

C15H17N3O2S

Mol. Mass.:

303.379

SMILES:

Cc1nnc2sc(C(=O)NC3COC3)c(C3CC3)c2c1C

Structure:

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