Target

Ligand

Substrate

Meas. Tech.

ChEMBL_1872177 (CHEMBL4373344)

Citation

 Poslusney, MS; Salovich, JM; Wood, MR; Melancon, BJ; Bollinger, KA; Luscombe, VB; Rodriguez, AL; Engers, DW; Bridges, TM; Niswender, CM; Conn, PJ; Lindsley, CW Novel M Bioorg Med Chem Lett 29:362-366 (2019) [PubMed]  Article

More Info.:

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Name:

Muscarinic acetylcholine receptor M4

Synonyms:

ACM4_HUMAN | CHRM4 | Cholinergic, muscarinic M4 | Muscarinic acetylcholine receptor | Muscarinic acetylcholine receptor M2 and M4

Type:

Enzyme Catalytic Domain

Mol. Mass.:

53079.31

Organism:

Homo sapiens (Human)

Description:

Cholinergic, muscarinic M4 CHRM4 HUMAN M3::P08173

Residue:

479

Sequence:

MANFTPVNGSSGNQSVRLVTSSSHNRYETVEMVFIATVTGSLSLVTVVGNILVMLSIKVNRQLQTVNNYFLFSLACADLIIGAFSMNLYTVYIIKGYWPLGAVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPARRTTKMAGLMIAAAWVLSFVLWAPAILFWQFVVGKRTVPDNQCFIQFLSNPAVTFGTAIAAFYLPVVIMTVLYIHISLASRSRVHKHRPEGPKEKKAKTLAFLKSPLMKQSVKKPPPGEAAREELRNGKLEEAPPPALPPPPRPVADKDTSNESSSGSATQNTKERPATELSTTEATTPAMPAPPLQPRALNPASRWSKIQIVTKQTGNECVTAIEIVPATPAGMRPAANVARKFASIARNQVRKKRQMAARERKVTRTIFAILLAFILTWTPYNVMVLVNTFCQSCIPDTVWSIGYWLCYVNSTINPACYALCNATFKKTFRHLLLCQYRNIGTAR

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Name:

BDBM50518705

Synonyms:

CHEMBL4536563

Type:

Small organic molecule

Emp. Form.:

C19H17F3N2O2S

Mol. Mass.:

394.411

SMILES:

Cc1c(sc2nc(C)cc(C)c12)C(=O)NCc1ccc(OC(F)(F)F)cc1

Structure:

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