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Target
Mucosa-associated lymphoid tissue lymphoma translocation protein 1
Ligand
BDBM50518786
Substrate
n/a
Meas. Tech.
ChEMBL_1872263 (CHEMBL4373430)
IC50
50900±n/a nM
Citation
 Tran, TD; Wilson, BAP; Henrich, CJ; Staudt, LM; Krumpe, LRH; Smith, EA; King, J; Wendt, KL; Stchigel, AM; Miller, AN; Cichewicz, RH; O'Keefe, BR; Gustafson, KR Secondary Metabolites from the Fungus Dictyosporium sp. and Their MALT1 Inhibitory Activities. J Nat Prod 82:154-162 (2019) [PubMed]  Article
Target
Name:
Mucosa-associated lymphoid tissue lymphoma translocation protein 1
Synonyms:
MALT lymphoma-associated translocation | MALT lymphoma-associated translocation (MALT1) | MALT1 | MALT1_HUMAN | MLT | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | Paracaspase
Type:
Enzyme
Mol. Mass.:
92257.81
Organism:
Homo sapiens (Human)
Description:
Q9UDY8
Residue:
824
Sequence:
MSLLGDPLQALPPSAAPTGPLLAPPAGATLNRLREPLLRRLSELLDQAPEGRGWRRLAELAGSRGRLRLSCLDLEQCSLKVLEPEGSPSLCLLKLMGEKGCTVTELSDFLQAMEHTEVLQLLSPPGIKITVNPESKAVLAGQFVKLCCRATGHPFVQYQWFKMNKEIPNGNTSELIFNAVHVKDAGFYVCRVNNNFTFEFSQWSQLDVCDIPESFQRSVDGVSESKLQICVEPTSQKLMPGSTLVLQCVAVGSPIPHYQWFKNELPLTHETKKLYMVPYVDLEHQGTYWCHVYNDRDSQDSKKVEIIIGRTDEAVECTEDELNNLGHPDNKEQTTDQPLAKDKVALLIGNMNYREHPKLKAPLVDVYELTNLLRQLDFKVVSLLDLTEYEMRNAVDEFLLLLDKGVYGLLYYAGHGYENFGNSFMVPVDAPNPYRSENCLCVQNILKLMQEKETGLNVFLLDMCRKRNDYDDTIPILDALKVTANIVFGYATCQGAEAFEIQHSGLANGIFMKFLKDRLLEDKKITVLLDEVAEDMGKCHLTKGKQALEIRSSLSEKRALTDPIQGTEYSAESLVRNLQWAKAHELPESMCLKFDCGVQIQLGFAAEFSNVMIIYTSIVYKPPEIIMCDAYVTDFPLDLDIDPKDANKGTPEETGSYLVSKDLPKHCLYTRLSSLQKLKEHLVFTVCLSYQYSGLEDTVEDKQEVNVGKPLIAKLDMHRGLGRKTCFQTCLMSNGPYQSSAATSGGAGHYHSLQDPFHGVYHSHPGNPSNVTPADSCHCSRTPDAFISSFAHHASCHFSRSNVPVETTDEIPFSFSDRLRISEK
  
Inhibitor
Name:
BDBM50518786
Synonyms:
CHEMBL4575326
Type:
Small organic molecule
Emp. Form.:
C16H12O6
Mol. Mass.:
300.2629
SMILES:
COC(=O)C1=CC=COc2oc3cc(C)cc(O)c3c(=O)c12 |c:6,t:4|
Structure:
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