Reaction Details Report a problem with these data
Target
Gag-Pol polyprotein [489-587]
Ligand
BDBM50073367
Substrate
n/a
Meas. Tech.
ChEBML_157552
Ki
1500±n/a nM
Citation
Salituro, FG; Baker, CT; Court, JJ; Deininger, DD; Kim, EE; Li, B; Novak, PM; Rao, BG; Pazhanisamy, S; Porter, MD; Schairer, WC; Tung, RD Design and synthesis of novel conformationally restricted HIV protease inhibitors. Bioorg Med Chem Lett 8:3637-42 (1999) [PubMed]
More Info.:
Target
Name:
Gag-Pol polyprotein [489-587]
Synonyms:
Human immunodeficiency virus type 1 protease | POL_HV1H2 | Pol polyprotein | gag-pol
Type:
Enzyme Subunit
Mol. Mass.:
10781.16
Organism:
Human immunodeficiency virus type 1
Description:
P04585[489-587]
Residue:
99
Sequence:
PQVTLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMSLPGRWKPKMIGGIGGFIKVRQYDQILIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF
Inhibitor
Name:
BDBM50073367
Synonyms:
CHEMBL420158 | N-[(S)-3-((S)-4-Benzyl-2-oxo-oxazolidin-3-yl)-2-hydroxy-propyl]-N-cyclopentylmethyl-4-methoxy-benzenesulfonamide
Type:
Small organic molecule
Emp. Form.:
C26H34N2O6S
Mol. Mass.:
502.623
SMILES:
COc1ccc(cc1)S(=O)(=O)N(C[C@@H](O)CN1[C@@H](Cc2ccccc2)COC1=O)CC1CCCC1