Reaction Details  Report a problem with these data
Target
Histone deacetylase 1
Ligand
BDBM50519507
Substrate
n/a
Meas. Tech.
ChEMBL_1875849 (CHEMBL4377243)
IC50
27±n/a nM
Citation
 Ling, Y; Li, Y; Zhu, R; Qian, J; Liu, J; Gao, W; Meng, C; Miao, J; Xiong, B; Qiu, X; Ling, C; Dai, H; Zhang, Y Hydroxamic Acid Derivatives of ?-Carboline/Hydroxycinnamic Acid Hybrids Inducing Apoptosis and Autophagy through the PI3K/Akt/mTOR Pathways. J Nat Prod 82:1442-1450 (2019) [PubMed]  Article
Target
Name:
Histone deacetylase 1
Synonyms:
Cereblon/Histone deacetylase 1 | HD1 | HDAC1 | HDAC1_HUMAN | Histone deacetylase 1 (HDAC1) | Human HDAC1 | RPD3L1
Type:
Enzyme
Mol. Mass.:
55090.27
Organism:
Homo sapiens (Human)
Description:
Q13547
Residue:
482
Sequence:
MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKANAEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVASAVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAIFKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGGGGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLEKIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEFSDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVKLA
  
Inhibitor
Name:
BDBM50519507
Synonyms:
CHEMBL4442355
Type:
Small organic molecule
Emp. Form.:
C31H30N4O5
Mol. Mass.:
538.5937
SMILES:
COc1ccc(cc1)-c1nc(NCCCOc2ccc(\C=C\C(=O)NO)cc2OC)cc2c3ccccc3[nH]c12
Structure:
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