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Target
Spindlin-1
Ligand
BDBM50505575
Substrate
n/a
Meas. Tech.
ChEMBL_1875889 (CHEMBL4377283)
Kd
3000±n/a nM
Citation
 Xiong, Y; Greschik, H; Johansson, C; Seifert, L; Bacher, J; Park, KS; Babault, N; Martini, M; Fagan, V; Li, F; Chau, I; Christott, T; Dilworth, D; Barsyte-Lovejoy, D; Vedadi, M; Arrowsmith, CH; Brennan, P; Fedorov, O; Jung, M; Farnie, G; Liu, J; Oppermann, U; Schüle, R; Jin, J Discovery of a Potent and Selective Fragment-like Inhibitor of Methyllysine Reader Protein Spindlin 1 (SPIN1). J Med Chem 62:8996-9007 (2019) [PubMed]  Article
Target
Name:
Spindlin-1
Synonyms:
OCR | Ovarian cancer-related protein | SPIN | SPIN1 | SPIN1_HUMAN | Spindlin-1 | Spindlin1
Type:
PROTEIN
Mol. Mass.:
29602.24
Organism:
Homo sapiens
Description:
ChEMBL_119259
Residue:
262
Sequence:
MKTPFGKTPGQRSRADAGHAGVSANMMKKRTSHKKHRSSVGPSKPVSQPRRNIVGCRIQHGWKEGNGPVTQWKGTVLDQVPVNPSLYLIKYDGFDCVYGLELNKDERVSALEVLPDRVATSRISDAHLADTMIGKAVEHMFETEDGSKDEWRGMVLARAPVMNTWFYITYEKDPVLYMYQLLDDYKEGDLRIMPDSNDSPPAEREPGEVVDSLVGKQVEYAKEDGSKRTGMVIHQVEAKPSVYFIKFDDDFHIYVYDLVKTS
  
Inhibitor
Name:
BDBM50505575
Synonyms:
CHEMBL4476514
Type:
Small organic molecule
Emp. Form.:
C41H60N6O3
Mol. Mass.:
684.9535
SMILES:
O=C(N1CCC(CCN2CCCC2)CC1)c1ccc(C(=O)N2CCC(CCN3CCCC3)CC2)c(Nc2ccc(OCN3CCCC3)cc2)c1
Structure:
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