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Target
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A
Ligand
BDBM50073695
Substrate
n/a
Meas. Tech.
ChEBML_156007
IC50
15±n/a nM
Citation
 Ho, GD; Silverman, L; Bercovici, A; Puchalski, C; Tulshian, D; Xia, Y; Czarniecki, M; Green, M; Cleven, R; Zhang, H; Fawzi, A Synthesis and evaluation of potent and selective c-GMP phosphodiesterase inhibitors. Bioorg Med Chem Lett 9:7-12 (1999) [PubMed]
Target
Name:
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A
Synonyms:
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A | Heart phosphodiesterase | PDE1A | PDE1A_BOVIN | Phosphodiesterase 1 | Phosphodiesterase 1A
Type:
Enzyme Catalytic Domain
Mol. Mass.:
60835.05
Organism:
BOVINE
Description:
Phosphodiesterase 1 0 BOVINE::P14100
Residue:
530
Sequence:
MGSTATETEELENTTFKYLIGEQTEKMWQRLKGILRCLVKQLEKGDVNVIDLKKNIEYAASVLEAVYIDETRRLLDTDDELSDIQSDSVPSEVRDWLASTFTRKMGMMKKKSEEKPRFRSIVHVVQAGIFVERMYRKSYHMVGLAYPEAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLIAFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNVLINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGLDKAKTMSLILHAADISHPAKSWKLHHRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIIIPLIEEDSKTKTPSYGASRRSNMKGTTNDGTYSPDYSLASVDLKSFKNSLVDIIQQNKERWKELAAQGEPDPHKNSDLVNAEEKHAETHS
  
Inhibitor
Name:
BDBM50073695
Synonyms:
(R)-7-Isopropyl-5-methyl-2-(3-methyl-butyl)-7,8-dihydro-3H,5H-imidazo[2,1-b]purin-4-one | CHEMBL19157
Type:
Small organic molecule
Emp. Form.:
C16H25N5O
Mol. Mass.:
303.4026
SMILES:
CC(C)CCc1nc2N3C[C@H](N=C3N(C)C(=O)c2[nH]1)C(C)C |c:11|
Structure:
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