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Target
Prothrombin
Ligand
BDBM50075123
Substrate
n/a
Meas. Tech.
ChEBML_225422
IC50
600±n/a nM
Citation
 Pass, M; Bolton, RE; Coote, SJ; Finch, H; Hindley, S; Lowdon, A; McDonald, E; McLaren, J; Owen, M; Pegg, NA; Mooney, CJ; Tang, CM; Parry, S; Patel, C Synthetic [5,5] trans-fused indane lactones as inhibitors of thrombin. Bioorg Med Chem Lett 9:431-6 (1999) [PubMed]
Target
Name:
Prothrombin
Synonyms:
Activation peptide fragment 1 | Activation peptide fragment 2 | Coagulation factor II | F2 | Prothrombin precursor | THRB_HUMAN | Thrombin heavy chain | Thrombin light chain
Type:
Protein
Mol. Mass.:
70029.57
Organism:
Homo sapiens (Human)
Description:
P00734
Residue:
622
Sequence:
MAHVRGLQLPGCLALAALCSLVHSQHVFLAPQQARSLLQRVRRANTFLEEVRKGNLERECVEETCSYEEAFEALESSTATDVFWAKYTACETARTPRDKLAACLEGNCAEGLGTNYRGHVNITRSGIECQLWRSRYPHKPEINSTTHPGADLQENFCRNPDSSTTGPWCYTTDPTVRRQECSIPVCGQDQVTVAMTPRSEGSSVNLSPPLEQCVPDRGQQYQGRLAVTTHGLPCLAWASAQAKALSKHQDFNSAVQLVENFCRNPDGDEEGVWCYVAGKPGDFGYCDLNYCEEAVEEETGDGLDEDSDRAIEGRTATSEYQTFFNPRTFGSGEADCGLRPLFEKKSLEDKTERELLESYIDGRIVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETWTANVGKGQPSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQFGE
  
Inhibitor
Name:
BDBM50075123
Synonyms:
4-((3R,3aS,8aS)-2-Oxo-3,3a,8,8a-tetrahydro-2H-indeno[2,1-b]furan-3-yl)-butyramidine | CHEMBL136980
Type:
Small organic molecule
Emp. Form.:
C15H18N2O2
Mol. Mass.:
258.3156
SMILES:
NC(=N)CCC[C@@H]1[C@@H]2[C@H](Cc3ccccc23)OC1=O
Structure:
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