Reaction Details  Report a problem with these data
Target
Somatostatin receptor type 2
Ligand
BDBM50075284
Substrate
n/a
Meas. Tech.
ChEBML_200682
Ki
18±n/a nM
Citation
 Pasternak, A; Pan, Y; Marino, D; Sanderson, PE; Mosley, R; Rohrer, SP; Birzin, ET; Huskey, SE; Jacks, T; Schleim, KD; Cheng, K; Schaeffer, JM; Patchett, AA; Yang, L Potent, orally bioavailable somatostatin agonists: good absorption achieved by urea backbone cyclization. Bioorg Med Chem Lett 9:491-6 (1999) [PubMed]
Target
Name:
Somatostatin receptor type 2
Synonyms:
SOMATOSTATIN SST2 | SRIF-1 | SS-2-R | SS2-R | SS2R | SSR2_HUMAN | SSTR2 | Somatostatin receptor type 2 (SSTR2)
Type:
Enzyme
Mol. Mass.:
41344.94
Organism:
Homo sapiens (Human)
Description:
P30874
Residue:
369
Sequence:
MDMADEPLNGSHTWLSIPFDLNGSVVSTNTSNQTEPYYDLTSNAVLTFIYFVVCIIGLCGNTLVIYVILRYAKMKTITNIYILNLAIADELFMLGLPFLAMQVALVHWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPIMIYAGLRSNQWGRSSCTINWPGESGAWYTGFIIYTFILGFLVPLTIICLCYLFIIIKVKSSGIRVGSSKRKKSEKKVTRMVSIVVAVFIFCWLPFYIFNVSSVSMAISPTPALKGMFDFVVVLTYANSCANPILYAFLSDNFKKSFQNVLCLVKVSGTDDGERSDSKQDKSRLNETTETQRTLLNGDLQTSI
  
Inhibitor
Name:
BDBM50075284
Synonyms:
(2R,3S)-N-(5-Amino-[1,3]dioxan-2-ylmethyl)-3-(1H-indol-3-yl)-2-[2-oxo-3-(3-phenyl-propyl)-imidazolidin-1-yl]-butyramide | CHEMBL147939
Type:
Small organic molecule
Emp. Form.:
C29H37N5O4
Mol. Mass.:
519.6352
SMILES:
C[C@H]([C@@H](N1CCN(CCCc2ccccc2)C1=O)C(=O)NC[C@H]1OC[C@H](N)CO1)c1c[nH]c2ccccc12 |wU:2.2,22.23,wD:25.27,1.0,(-.51,3.82,;-.49,2.28,;.85,1.51,;2.17,2.29,;2.15,3.82,;4.83,3.84,;4.84,2.3,;6.18,1.55,;7.49,2.32,;8.85,1.56,;10.17,2.35,;10.15,3.89,;11.47,4.66,;12.83,3.91,;12.83,2.36,;11.51,1.58,;3.51,1.53,;3.52,-.01,;.85,-.02,;2.39,-.03,;.07,-1.35,;.82,-2.69,;.05,-4.01,;.82,-5.35,;.03,-6.68,;-1.52,-6.67,;-2.3,-7.98,;-2.26,-5.33,;-1.48,-4,;-1.82,1.49,;-1.81,-.03,;-3.14,-.82,;-4.47,-.05,;-5.81,-.82,;-7.14,-.05,;-7.14,1.49,;-5.81,2.26,;-4.47,1.49,)|
Structure:
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