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Target
Thromboxane A2 receptor
Ligand
BDBM50075631
Substrate
n/a
Meas. Tech.
ChEMBL_209591 (CHEMBL814726)
IC50
310±n/a nM
Citation
 Soyka, R; Guth, BD; Weisenberger, HM; Luger, P; Müller, TH Guanidine derivatives as combined thromboxane A2 receptor antagonists and synthase inhibitors. J Med Chem 42:1235-49 (1999) [PubMed]  Article
Target
Name:
Thromboxane A2 receptor
Synonyms:
Prostanoid TP receptor | TA2R_HUMAN | TBXA2R | TXA2-R | Thromboxane | Thromboxane A2 receptor | Thromboxane Beta
Type:
Enyzme
Mol. Mass.:
37445.28
Organism:
Homo sapiens (Human)
Description:
P21731
Residue:
343
Sequence:
MWPNGSSLGPCFRPTNITLEERRLIASPWFAASFCVVGLASNLLALSVLAGARQGGSHTRSSFLTFLCGLVLTDFLGLLVTGTIVVSQHAALFEWHAVDPGCRLCRFMGVVMIFFGLSPLLLGAAMASERYLGITRPFSRPAVASQRRAWATVGLVWAAALALGLLPLLGVGRYTVQYPGSWCFLTLGAESGDVAFGLLFSMLGGLSVGLSFLLNTVSVATLCHVYHGQEAAQQRPRDSEVEMMAQLLGIMVVASVCWLPLLVFIAQTVLRNPPAMSPAGQLSRTTEKELLIYLRVATWNQILDPWVYILFRRAVLRRLQPRLSTRPRSLSLQPQLTQRSGLQ
  
Inhibitor
Name:
BDBM50075631
Synonyms:
5-[2-{3-[1-(tert-butylamino)-2-cyano-(Z)-1-iminomethylamino]phenyl}-2-(3-pyridyl)-(E)-1-methyleneaminooxy]pentanoic acid | 5-[2-{3-[1-(tert-butylamino)-2-cyano-(Z)-1-iminomethylamino]phenyl}-2-(3-pyridyl)-(Z)-1-methyleneaminooxy]pentanoic acid | CHEMBL22023
Type:
Small organic molecule
Emp. Form.:
C23H28N6O3
Mol. Mass.:
436.5068
SMILES:
CC(C)(C)NC(Nc1cccc(c1)C(=N/OCCCCC(O)=O)\c1cccnc1)=NC#N |w:29.31|
Structure:
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