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Target
Corticotropin-releasing factor receptor 2
Ligand
BDBM50075920
Substrate
n/a
Meas. Tech.
ChEBML_51277
Ki
>10000±n/a nM
Citation
 Luthin, DR; Rabinovich, AK; Bhumralkar, DR; Youngblood, KL; Bychowski, RA; Dhanoa, DS; May, JM Synthesis and biological activity of oxo-7H-benzo[e]perimidine-4-carboxylic acid derivatives as potent, nonpeptide corticotropin releasing factor (CRF) receptor antagonists. Bioorg Med Chem Lett 9:765-70 (1999) [PubMed]
Target
Name:
Corticotropin-releasing factor receptor 2
Synonyms:
CRF-R-2 | CRF-R2 | CRF-RB | CRFR-2 | CRFR2_MOUSE | CRH-R-2 | CRH-R2 | Corticotropin releasing factor receptor 2 | Corticotropin-releasing factor receptor 2 | Corticotropin-releasing hormone receptor 2 | Crf2r | Crhr2
Type:
PROTEIN
Mol. Mass.:
47628.12
Organism:
Mus musculus
Description:
ChEMBL_51276
Residue:
411
Sequence:
MDAALLLSLLEANCSLALAEELLLDGWGVPPDPEGPYTYCNTTLDQIGTCWPQSAPGALVERPCPEYFNGIKYNTTRNAYRECLENGTWASRVNYSHCEPILDDKQRKYDLHYRIALIVNYLGHCVSVVALVAAFLLFLVLRSIRCLRNVIHWNLITTFILRNIAWFLLQLIDHEVHEGNEVWCRCITTIFNYFVVTNFFWMFVEGCYLHTAIVMTYSTEHLRKWLFLFIGWCIPCPIIIAWAVGKLYYENEQCWFGKEAGDLVDYIYQGPVMLVLLINFVFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDDLSQIVFIYFNSFLQSFQGFFVSVFYCFFNGEVRAALRKRWHRWQDHHALRVPVARAMSIPTSPTRISFHSIKQTAAV
  
Inhibitor
Name:
BDBM50075920
Synonyms:
7-Oxo-7H-benzo[e]perimidine-4-carboxylic acid ((1R,2R)-2-amino-cyclohexyl)-amide | CHEMBL352131
Type:
Small organic molecule
Emp. Form.:
C22H20N4O2
Mol. Mass.:
372.4198
SMILES:
N[C@@H]1CCCC[C@H]1NC(=O)c1ccc2C(=O)c3ccccc3-c3ncnc1c23
Structure:
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