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Target
Renin
Ligand
BDBM50077671
Substrate
n/a
Meas. Tech.
ChEBML_195787
IC50
41±n/a nM
Citation
 Vieira, E; Binggeli, A; Breu, V; Bur, D; Fischli, W; Güller, R; Hirth, G; Märki, HP; Müller, M; Oefner, C; Scalone, M; Stadler, H; Wilhelm, M; Wostl, W Substituted piperidines--highly potent renin inhibitors due to induced fit adaptation of the active site. Bioorg Med Chem Lett 9:1397-402 (1999) [PubMed]
Target
Name:
Renin
Synonyms:
Angiotensinogenase | REN | RENI_HUMAN
Type:
Enzyme
Mol. Mass.:
45058.99
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
406
Sequence:
MDGWRRMPRWGLLLLLWGSCTFGLPTDTTTFKRIFLKRMPSIRESLKERGVDMARLGPEWSQPMKRLTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRLYTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEMPALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRDSENSQSLGGQIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISGSTSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKKLCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALAR
  
Inhibitor
Name:
BDBM50077671
Synonyms:
(3R,4R)-3-(Naphthalen-2-ylmethoxy)-4-[4-(3-phenyl-[1,2,4]oxadiazol-5-ylmethoxy)-phenyl]-piperidine | CHEMBL431502
Type:
Small organic molecule
Emp. Form.:
C31H29N3O3
Mol. Mass.:
491.5803
SMILES:
C(Oc1ccc(cc1)[C@H]1CCNC[C@@H]1OCc1ccc2ccccc2c1)c1nc(no1)-c1ccccc1
Structure:
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