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Target
Endothelin-1 receptor
Ligand
BDBM50077927
Substrate
n/a
Meas. Tech.
ChEMBL_65479 (CHEMBL677308)
IC50
>25000±n/a nM
Citation
 Patt, WC; Cheng, XM; Repine, JT; Lee, C; Reisdorph, BR; Massa, MA; Doherty, AM; Welch, KM; Bryant, JW; Flynn, MA; Walker, DM; Schroeder, RL; Haleen, SJ; Keiser, JA Butenolide endothelin antagonists with improved aqueous solubility. J Med Chem 42:2162-8 (1999) [PubMed]  Article
Target
Name:
Endothelin-1 receptor
Synonyms:
EDNRA | EDNRA_HUMAN | ET-A | ETA | ETA-R | ETRA | Endothelin receptor type A | Endothelin receptor, ET-A/ET-B | hET-AR
Type:
Enzyme Catalytic Domain
Mol. Mass.:
48736.88
Organism:
Homo sapiens (Human)
Description:
P25101
Residue:
427
Sequence:
METLCLRASFWLALVGCVISDNPERYSTNLSNHVDDFTTFRGTELSFLVTTHQPTNLVLPSNGSMHNYCPQQTKITSAFKYINTVISCTIFIVGMVGNATLLRIIYQNKCMRNGPNALIASLALGDLIYVVIDLPINVFKLLAGRWPFDHNDFGVFLCKLFPFLQKSSVGITVLNLCALSVDRYRAVASWSRVQGIGIPLVTAIEIVSIWILSFILAIPEAIGFVMVPFEYRGEQHKTCMLNATSKFMEFYQDVKDWWLFGFYFCMPLVCTAIFYTLMTCEMLNRRNGSLRIALSEHLKQRREVAKTVFCLVVIFALCWFPLHLSRILKKTVYNEMDKNRCELLSFLLLMDYIGINLATMNSCINPIALYFVSKKFKNCFQSCLCCCCYQSKSLMTSVPMNGTSIQWKNHDQNNHNTDRSSHKDSMN
  
Inhibitor
Name:
BDBM50077927
Synonyms:
3-Benzo[1,3]dioxol-5-yl-4-[4-(3-dimethylamino-propoxy)-benzyl]-5-hydroxy-5-(4-methoxy-phenyl)-5H-furan-2-one | CHEMBL305035
Type:
Small organic molecule
Emp. Form.:
C30H31NO7
Mol. Mass.:
517.5696
SMILES:
COc1ccc(cc1)C1(O)OC(=O)C(=C1Cc1ccc(OCCCN(C)C)cc1)c1ccc2OCOc2c1 |c:14|
Structure:
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