Reaction Details  Report a problem with these data
Target
TYR_PHOSPHATASE_2 domain-containing protein
Ligand
BDBM50523064
Substrate
n/a
Meas. Tech.
ChEMBL_1888916 (CHEMBL4390593)
IC50
>50000±n/a nM
Citation
 Cai, R; Jiang, H; Mo, Y; Guo, H; Li, C; Long, Y; Zang, Z; She, Z Ophiobolin-Type Sesterterpenoids from the Mangrove Endophytic Fungus  J Nat Prod 82:2268-2278 (2019) [PubMed]  Article
Target
Name:
TYR_PHOSPHATASE_2 domain-containing protein
Synonyms:
(PROTEIN-TYROSINE-PHOSPHATASE) (PTPase) | MPtpB | PHOSPHOTYROSINE PROTEIN PHOSPHATASE PTPB | Phosphotyrosine protein phosphatase | Phosphotyrosine-protein phosphatase PTPB | Protein Tyrosine Phosphatase PTPB
Type:
Hydrolase
Mol. Mass.:
30152.45
Organism:
Mycobacterium tuberculosis
Description:
n/a
Residue:
276
Sequence:
MAVRELPGAWNFRDVADTATALRPGRLFRSSELSRLDDAGRATLRRLGITDVADLRSSREVARRGPGRVPDGIDVHLLPFPDLADDDADDSAPHETAFKRLLTNDGSNGESGESSQSINDAATRYMTDEYRQFPTRNGAQRALHRVVTLLAAGRPVLTHCFAGKDRTGFVVALVLEAVGLDRDVIVADYLRSNDSVPQLRARISEMIQQRFDTELAPEVVTFTKARLSDGVLGVRAEYLAAARQTIDETYGSLGGYLRDAGISQATVNRMRGVLLG
  
Inhibitor
Name:
BDBM50523064
Synonyms:
CHEMBL4455307
Type:
Small organic molecule
Emp. Form.:
C25H36O4
Mol. Mass.:
400.5509
SMILES:
[H][C@@]1(CC[C@]2(C)C[C@]3([H])C(C)=CC(=O)[C@]3([H])\C(C=O)=C/C[C@@]12[H])[C@@H](C)\C=C/[C@@H](O)C(C)(C)O |r,c:10,19|
Structure:
Search PDB for entries with ligand similarity: