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Target
Prostaglandin G/H synthase 2
Ligand
BDBM50078688
Substrate
n/a
Meas. Tech.
ChEMBL_1892170 (CHEMBL4394091)
IC50
600±n/a nM
Citation
 Husain, A; Khan, SA; Iram, F; Iqbal, MA; Asif, M Insights into the chemistry and therapeutic potential of furanones: A versatile pharmacophore. Eur J Med Chem 171:66-92 (2019) [PubMed]  Article
Target
Name:
Prostaglandin G/H synthase 2
Synonyms:
1.14.99.1 | COX-2 | COX2 | Cyclooxygenase-2 | PGH synthase 2 | PGH2_CAVPO | PGHS-2 | PHS II | PTGS2 | Prostaglandin G/H synthase 2 | Prostaglandin H2 synthase 2 | Prostaglandin-endoperoxide synthase 2
Type:
PROTEIN
Mol. Mass.:
68892.53
Organism:
Cavia porcellus
Description:
ChEMBL_119011
Residue:
604
Sequence:
MLARALLLCAALALGQAANPCCSNPCQNRGECLSVGFDRYKCDCTRTGYYGENCTTPEFLTRIKLLLKPTPNTVHYILTHFKGVWNIVNNIPFLRNAIMIYVLTSRSHLIDSPPTYNAHYGYKSWEAFSNLSYYTRALPPVADDCPTPMGVKGKKELPDSNEVLEKVLLRRKFIPDPQGTNMMFAFFAQHFTHQFFKSDQKRGPAFTTGLAHGVDLSHIYGETLDRQHKLRLFKDGKMKYQIIDGEMYPPTVKETQVEMMYPPYIPEHARFAVGQEVFGLVPGLMMYATIWLREHNRVCDVLKQEHPEWDDERLFQTSRLILIGETIKIVIEDYVQHLSGYHFKLKFDPELLFNQQFQYQNRIASEFNTLYHWHPLLPDTFQIDDQVYNFQQFLYNNSILVEHGLTQFVESFTKQIAGRVAGGRNVPLAVQRVAKASIEHSRKMKYQSLNEYRKRFLMKPYTSFEELTGEKEMAAGLEALYGDIDAMELYPALLVEKPRPDAIFGETMVEMGAPFSLKGLMGNPICSPHYWKPSTFGGEVGFQIVNTASIQSLICNNVKGCPVTAFNLPDPQLAKTVTINASASHSRLEDLSPTVLLKGRSTEL
  
Inhibitor
Name:
BDBM50078688
Synonyms:
3-(3,4-Difluoro-phenyl)-4-(4-methanesulfonyl-phenyl)-5H-furan-2-one | 3-(3,4-difluorophenyl)-4-(4-(methylsulfonyl)phenyl)furan-2(5H)-one | CHEMBL18264
Type:
Small organic molecule
Emp. Form.:
C17H12F2O4S
Mol. Mass.:
350.337
SMILES:
CS(=O)(=O)c1ccc(cc1)C1=C(C(=O)OC1)c1ccc(F)c(F)c1 |t:11|
Structure:
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