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Target
Aromatase
Ligand
BDBM50079814
Substrate
n/a
Meas. Tech.
ChEBML_36051
IC50
200±n/a nM
Citation
 Vinh, TK; Ahmadi, M; Delgado, PO; Perez, SF; Walters, HM; Smith, HJ; Nicholls, PJ; Simons, C 1-[(Benzofuran-2-yl)phenylmethyl]-triazoles and -tetrazoles - potent competitive inhibitors of aromatase. Bioorg Med Chem Lett 9:2105-8 (1999) [PubMed]
Target
Name:
Aromatase
Synonyms:
ARO1 | Aromatase | CP19A_HUMAN | CYAR | CYP19 | CYP19A1 | CYPXIX | Cytochrome P-450AROM | Cytochrome P450 19A1 | Cytochrome P450 2C19 | Cytochrome P450-C19 (CYP19) | Estrogen synthetase | FL cytokine receptor precursor | P-450AROM
Type:
Enzyme
Mol. Mass.:
57888.92
Organism:
Homo sapiens (Human)
Description:
P11511
Residue:
503
Sequence:
MVLEMLNPIHYNITSIVPEAMPAATMPVLLLTGLFLLVWNYEGTSSIPGPGYCMGIGPLISHGRFLWMGIGSACNYYNRVYGEFMRVWISGEETLIISKSSSMFHIMKHNHYSSRFGSKLGLQCIGMHEKGIIFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTNESGYVDVLTLLRRVMLDTSNTLFLRIPLDESAIVVKIQGYFDAWQALLIKPDIFFKISWLYKKYEKSVKDLKDAIEVLIAEKRRRISTEEKLEECMDFATELILAEKRGDLTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVMENFIYESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHRLEFFPKPNEFTLENFAKNVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQGQCVESIQKIHDLSLHPDETKNMLEMIFTPRNSDRCLEH
  
Inhibitor
Name:
BDBM50079814
Synonyms:
1-[(4-Chloro-phenyl)-(2,3-dihydro-benzofuran-2-yl)-methyl]-1H-[1,2,4]triazole | CHEMBL291646
Type:
Small organic molecule
Emp. Form.:
C17H14ClN3O
Mol. Mass.:
311.766
SMILES:
Clc1ccc(cc1)C(C1Cc2ccccc2O1)n1cncn1
Structure:
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