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Target
Phosphatidylcholine:ceramide cholinephosphotransferase 2
Ligand
BDBM50182487
Substrate
n/a
Meas. Tech.
ChEMBL_1897471 (CHEMBL4399506)
IC50
4000±n/a nM
Citation
 Othman, MA; Yuyama, K; Murai, Y; Igarashi, Y; Mikami, D; Sivasothy, Y; Awang, K; Monde, K Malabaricone C as Natural Sphingomyelin Synthase Inhibitor against Diet-Induced Obesity and Its Lipid Metabolism in Mice. ACS Med Chem Lett 10:1154-1158 (2019) [PubMed]  Article
Target
Name:
Phosphatidylcholine:ceramide cholinephosphotransferase 2
Synonyms:
SGMS2 | SMS2 | SMS2_HUMAN | Sphingomyelin synthase 2
Type:
PROTEIN
Mol. Mass.:
42294.80
Organism:
Homo sapiens (Human)
Description:
ChEMBL_108027
Residue:
365
Sequence:
MDIIETAKLEEHLENQPSDPTNTYARPAEPVEEENKNGNGKPKSLSSGLRKGTKKYPDYIQIAMPTESRNKFPLEWWKTGIAFIYAVFNLVLTTVMITVVHERVPPKELSPPLPDKFFDYIDRVKWAFSVSEINGIILVGLWITQWLFLRYKSIVGRRFCFIIGTLYLYRCITMYVTTLPVPGMHFQCAPKLNGDSQAKVQRILRLISGGGLSITGSHILCGDFLFSGHTVTLTLTYLFIKEYSPRHFWWYHLICWLLSAAGIICILVAHEHYTIDVIIAYYITTRLFWWYHSMANEKNLKVSSQTNFLSRAWWFPIFYFFEKNVQGSIPCCFSWPLSWPPGCFKSSCKKYSRVQKIGEDNEKST
  
Inhibitor
Name:
BDBM50182487
Synonyms:
Malabaricone A
Type:
Small organic molecule
Emp. Form.:
C21H26O3
Mol. Mass.:
326.4293
SMILES:
Oc1cccc(O)c1C(=O)CCCCCCCCc1ccccc1
Structure:
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