Ki Summary

Reaction Details

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Target

Non-receptor tyrosine-protein kinase TYK2

Ligand

BDBM50526609

Substrate

n/a

Meas. Tech.

ChEMBL_1900331 (CHEMBL4402446)

340±n/a nM

Citation

Liu, C; Lin, J; Moslin, R; Tokarski, JS; Muckelbauer, J; Chang, C; Tredup, J; Xie, D; Park, H; Li, P; Wu, DR; Strnad, J; Zupa-Fernandez, A; Cheng, L; Chaudhry, C; Chen, J; Chen, C; Sun, H; Elzinga, P; D'arienzo, C; Gillooly, K; Taylor, TL; McIntyre, KW; Salter-Cid, L; Lombardo, LJ; Carter, PH; Aranibar, N; Burke, JR; Weinstein, DS Identification of Imidazo[1,2- ACS Med Chem Lett 10:383-388 (2019) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Target

Name:

Non-receptor tyrosine-protein kinase TYK2

Synonyms:

Non-receptor tyrosine-protein kinase TYK2 (TYK2) | TYK2 | TYK2_HUMAN | Tyrosine-protein kinase TYK2

Type:

Protein

Mol. Mass.:

133666.03

Organism:

Homo sapiens (Human)

Description:

P29597

Residue:

1187

Sequence:

MPLRHWGMARGSKPVGDGAQPMAAMGGLKVLLHWAGPGGGEPWVTFSESSLTAEEVCIHIAHKVGITPPCFNLFALFDAQAQVWLPPNHILEIPRDASLMLYFRIRFYFRNWHGMNPREPAVYRCGPPGTEASSDQTAQGMQLLDPASFEYLFEQGKHEFVNDVASLWELSTEEEIHHFKNESLGMAFLHLCHLALRHGIPLEEVAKKTSFKDCIPRSFRRHIRQHSALTRLRLRNVFRRFLRDFQPGRLSQQMVMVKYLATLERLAPRFGTERVPVCHLRLLAQAEGEPCYIRDSGVAPTDPGPESAAGPPTHEVLVTGTGGIQWWPVEEEVNKEEGSSGSSGRNPQASLFGKKAKAHKAVGQPADRPREPLWAYFCDFRDITHVVLKEHCVSIHRQDNKCLELSLPSRAAALSFVSLVDGYFRLTADSSHYLCHEVAPPRLVMSIRDGIHGPLLEPFVQAKLRPEDGLYLIHWSTSHPYRLILTVAQRSQAPDGMQSLRLRKFPIEQQDGAFVLEGWGRSFPSVRELGAALQGCLLRAGDDCFSLRRCCLPQPGETSNLIIMRGARASPRTLNLSQLSFHRVDQKEITQLSHLGQGTRTNVYEGRLRVEGSGDPEEGKMDDEDPLVPGRDRGQELRVVLKVLDPSHHDIALAFYETASLMSQVSHTHLAFVHGVCVRGPENIMVTEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFIKLSDPGVGLGALSREERVERIPWLAPECLPGGANSLSTAMDKWGFGATLLEICFDGEAPLQSRSPSEKEHFYQRQHRLPEPSCPQLATLTSQCLTYEPTQRPSFRTILRDLTRLQPHNLADVLTVNPDSPASDPTVFHKRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQHRSGWKQEIDILRTLYHEHIIKYKGCCEDQGEKSLQLVMEYVPLGSLRDYLPRHSIGLAQLLLFAQQICEGMAYLHAQHYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKEYKFYYASDVWSFGVTLYELLTHCDSSQSPPTKFLELIGIAQGQMTVLRLTELLERGERLPRPDKCPCEVYHLMKNCWETEASFRPTFENLIPILKTVHEKYQGQAPSVFSVC

Inhibitor

Name:

BDBM50526609

Synonyms:

CHEMBL4454109

Type:

Small organic molecule

Emp. Form.:

C21H23N9O2

Mol. Mass.:

433.4664

SMILES:

CNc1cc(Nc2cccn(-c3cc(C)n(C)n3)c2=O)nn2c(cnc12)C(=O)NC1CC1

Structure: