Reaction Details 
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Phospho-N-acetylmuramoyl-pentapeptide-transferase
Ligand
BDBM50526634
Substrate
n/a
Meas. Tech.
ChEMBL_1900500 (CHEMBL4402722)
IC50
100000±n/a nM
Citation
Patel, B; Ryan, P; Makwana, V; Zunk, M; Rudrawar, S; Grant, G Caprazamycins: Promising lead structures acting on a novel antibacterial target MraY. Eur J Med Chem 171:462-474 (2019) [PubMed] ArticleMore Info.:
Target
Name:
Phospho-N-acetylmuramoyl-pentapeptide-transferase
Synonyms:
MRAY_BACSU | mraY
Type:
PROTEIN
Mol. Mass.:
35531.14
Organism:
Bacillus subtilis
Description:
ChEMBL_796247
Residue:
324
Sequence:
MLEQVILFTILMGFLISVLLSPILIPFLRRLKFGQSIREEGPKSHQKKSGTPTMGGVMIILSIIVTTIVMTQKFSEISPEMVLLLFVTLGYGLLGFLDDYIKVVMKRNLGLTSKQKLIGQIIIAVVFYAVYHYYNFATDIRIPGTDLSFDLGWAYFILVLFMLVGGSNAVNLTDGLDGLLSGTAAIAFGAFAILAWNQSQYDVAIFSVAVVGAVLGFLVFNAHPAKVFMGDTGSLALGGAIVTIAILTKLEILLVIIGGVFVIETLSVILQVISFKTTGKRIFKMSPLHHHYELVGWSEWRVVVTFWAAGLLLAVLGIYIEVWL
Inhibitor
Name:
BDBM50526634
Synonyms:
CHEMBL4538396
Type:
Small organic molecule
Emp. Form.:
C34H37F3N6O13
Mol. Mass.:
794.6852
SMILES:
OC(=O)C(F)(F)F.[H][C@@]1(O[C@@H](c2cn(CCCOc3ccc(cc3)C(=O)c3ccccc3)nn2)[C@@]2([H])O[C@H]([C@H](O)[C@@H]2O)n2ccc(=O)[nH]c2=O)O[C@H](CN)[C@@H](O)[C@H]1O |r|
Structure:
