Reaction Details 
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Phospho-N-acetylmuramoyl-pentapeptide-transferase
Ligand
BDBM50526655
Substrate
n/a
Meas. Tech.
ChEMBL_1900500 (CHEMBL4402722)
IC50
125000±n/a nM
Citation
Patel, B; Ryan, P; Makwana, V; Zunk, M; Rudrawar, S; Grant, G Caprazamycins: Promising lead structures acting on a novel antibacterial target MraY. Eur J Med Chem 171:462-474 (2019) [PubMed] ArticleMore Info.:
Target
Name:
Phospho-N-acetylmuramoyl-pentapeptide-transferase
Synonyms:
MRAY_BACSU | mraY
Type:
PROTEIN
Mol. Mass.:
35531.14
Organism:
Bacillus subtilis
Description:
ChEMBL_796247
Residue:
324
Sequence:
MLEQVILFTILMGFLISVLLSPILIPFLRRLKFGQSIREEGPKSHQKKSGTPTMGGVMIILSIIVTTIVMTQKFSEISPEMVLLLFVTLGYGLLGFLDDYIKVVMKRNLGLTSKQKLIGQIIIAVVFYAVYHYYNFATDIRIPGTDLSFDLGWAYFILVLFMLVGGSNAVNLTDGLDGLLSGTAAIAFGAFAILAWNQSQYDVAIFSVAVVGAVLGFLVFNAHPAKVFMGDTGSLALGGAIVTIAILTKLEILLVIIGGVFVIETLSVILQVISFKTTGKRIFKMSPLHHHYELVGWSEWRVVVTFWAAGLLLAVLGIYIEVWL
Inhibitor
Name:
BDBM50526655
Synonyms:
CHEMBL4569198
Type:
Small organic molecule
Emp. Form.:
C39H50N6O11
Mol. Mass.:
778.8479
SMILES:
[H][C@@]1(O[C@H]([C@H](O)[C@@H]1O)n1ccc(=O)[nH]c1=O)[C@@H](O[C@@H]1O[C@H](CN)[C@@H](O)[C@H]1O)c1cn(CCCCCCCCCCOc2ccc(cc2)C(=O)c2ccccc2)nn1 |r|
Structure:
