Reaction Details  Report a problem with these data
Target
Superoxide dismutase [Cu-Zn]
Ligand
BDBM50526703
Substrate
n/a
Meas. Tech.
ChEMBL_1900857 (CHEMBL4403079)
IC50
>50000±n/a nM
Citation
 Paucar, R; Martín-Escolano, R; Moreno-Viguri, E; Azqueta, A; Cirauqui, N; Marín, C; Sánchez-Moreno, M; Pérez-Silanes, S Rational modification of Mannich base-type derivatives as novel antichagasic compounds: Synthesis, in vitro and in vivo evaluation. Bioorg Med Chem 27:3902-3917 (2019) [PubMed]  Article
Target
Name:
Superoxide dismutase [Cu-Zn]
Synonyms:
SOD1 | SODC_HUMAN | Superoxide dismutase
Type:
PROTEIN
Mol. Mass.:
15933.55
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1444880
Residue:
154
Sequence:
MATKAVCVLKGDGPVQGIINFEQKESNGPVKVWGSIKGLTEGLHGFHVHEFGDNTAGCTSAGPHFNPLSRKHGGPKDEERHVGDLGNVTADKDGVADVSIEDSVISLSGDHCIIGRTLVVHEKADDLGKGGNEESTKTGNAGSRLACGVIGIAQ
  
Inhibitor
Name:
BDBM50526703
Synonyms:
CHEMBL4475359
Type:
Small organic molecule
Emp. Form.:
C20H21F3N2O2
Mol. Mass.:
378.3881
SMILES:
Oc1ccc(cc1)C(=O)CCN1CCN(CC1)c1ccc(cc1)C(F)(F)F
Structure:
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