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Target
Proteasome subunit beta type-1
Ligand
BDBM50398608
Substrate
n/a
Meas. Tech.
ChEMBL_1901149 (CHEMBL4403371)
IC50
0.604000±n/a nM
Citation
 Xi, J; Zhuang, R; Kong, L; He, R; Zhu, H; Zhang, J Immunoproteasome-selective inhibitors: An overview of recent developments as potential drugs for hematologic malignancies and autoimmune diseases. Eur J Med Chem 182:0 (2019) [PubMed]  Article
Target
Name:
Proteasome subunit beta type-1
Synonyms:
PSB1_HUMAN | PSC5 | PSMB1 | Proteasome component C5 | Proteasome subunit beta type-1/beta type-5
Type:
PROTEIN
Mol. Mass.:
26493.62
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1366691
Residue:
241
Sequence:
MLSSTAMYSAPGRDLGMEPHRAAGPLQLRFSPYVFNGGTILAIAGEDFAIVASDTRLSEGFSIHTRDSPKCYKLTDKTVIGCSGFHGDCLTLTKIIEARLKMYKHSNNKAMTTGAIAAMLSTILYSRRFFPYYVYNIIGGLDEEGKGAVYSFDPVGSYQRDSFKAGGSASAMLQPLLDNQVGFKNMQNVEHVPLSLDRAMRLVKDVFISAAERDVYTGDALRICIVTKEGIREETVSLRKD
  
Inhibitor
Name:
BDBM50398608
Synonyms:
MARIZOMIB
Type:
Small organic molecule
Emp. Form.:
C15H20ClNO4
Mol. Mass.:
313.777
SMILES:
C[C@@]12OC(=O)[C@@]1(NC(=O)[C@@H]2CCCl)[C@@H](O)[C@H]1CCCC=C1 |r,c:21|
Structure:
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