Reaction Details Report a problem with these data
Target
Lanosterol synthase
Ligand
BDBM50529571
Substrate
n/a
Meas. Tech.
ChEMBL_1908867 (CHEMBL4411225)
IC50
40±n/a nM
Citation
Ernst, G; Akuma, D; Au, V; Buchler, IP; Byers, S; Carr, GV; Defays, S; de León, P; Demaude, T; DePasquale, M; Durieu, V; Huang, Y; Jigorel, E; Kimos, M; Kolobova, A; Montel, F; Moureau, F; Poslusney, M; Swinnen, D; Vandergeten, MC; Van Houtvin, N; Wei, H; White, N; Wood, M; Barrow, JC Synthesis and Evaluation of Bicyclic Hydroxypyridones as Inhibitors of Catechol ACS Med Chem Lett 10:1573-1578 (2019) [PubMed] Article
More Info.:
Target
Name:
Lanosterol synthase
Synonyms:
LSS_RAT | Lss | Osc
Type:
PROTEIN
Mol. Mass.:
83302.12
Organism:
Rattus norvegicus
Description:
ChEMBL_12083
Residue:
733
Sequence:
MTEGTCLRRRGGPYKTEPATDLTRWRLHNELGRQRWTYYQAEEDPGREQTGLEAHSLGLDTTSYFKNLPKAQTAHEGALNGVTFYAKLQAEDGHWAGDYGGPLFLLPGLLITCHIAHIPLPAGYREEMVRYLRSVQLPDGGWGLHIEDKSTVFGTALSYVSLRILGIGPDDPDLVRARNILHKKGGAVAIPSWGKFWLAVLNVYSWEGINTLFPEMWLLPEWFPAHPSTLWCHCRQVYLPMSYCYATRLSASEDPLVQSLRQELYVEDYASIDWPAQKNNVCPDDMYTPHSWLLHVVYGLLNLYERFHSTSLRKWAIQLLYEHVAADDRFTKCISIGPISKTVNMLIRWSVDGPSSPAFQEHVSRIKDYLWLGLDGMKMQGTNGSQTWDTSFAVQALLEAGAHRRPEFLPCLQKAHEFLRLSQVPDNNPDYQKYYRHMHKGGFPFSTLDCGWIVADCTAEALKAVLLLQERCPSITEHVPRERLYDAVAVLLSMRNSDGGFATYETKRGGYLLELLNPSEVFGDIMIDYTYVECTSAVMQALRHFREYFPDHRATESRETLNQGLDFCRKKQRADGSWEGSWGVCFTYGTWFGLEAFACMGHIYQNRTACAEVAQACHFLLSRQMADGGWGEDFESCEQRRYVQSAGSQVHSTCWALLGLMAVRHPDISAQERGIRCLLGKQLPNGDWPQENISGVFNKSCAISYTNYRNIFPIWALGRFSSLYPDNTLAGHI