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Target
Glucose-6-phosphatase catalytic subunit 1
Ligand
BDBM50529620
Substrate
n/a
Meas. Tech.
ChEMBL_1909269 (CHEMBL4411715)
IC50
4800±n/a nM
Citation
 Kasangana, PB; Haddad, PS; Eid, HM; Nachar, A; Stevanovic, T Bioactive Pentacyclic Triterpenes from the Root Bark Extract of Myrianthus arboreus, a Species Used Traditionally to Treat Type-2 Diabetes. J Nat Prod 81:2169-2176 (2018) [PubMed]  Article
Target
Name:
Glucose-6-phosphatase catalytic subunit 1
Synonyms:
G-6-Pase | G6PC1_RAT | G6Pase | G6pc | G6pc1 | G6pt | Glucose-6-phosphatase
Type:
PROTEIN
Mol. Mass.:
40569.69
Organism:
Rattus norvegicus
Description:
ChEMBL_835198
Residue:
357
Sequence:
MEERMNVLHDFGIQSTRYLQVNYEDSQDWFVLVSVIADLRNAFYVLFPIWFHIQETVGINLLWVAVVGDWFNLVFKWILFGQRPYWWVLDTDYYSNSSVPLIKQFPVTCETGPGSPSGHAMGTAGVYYVMVTSTLAIFRGKKKSTYGFRCLNVVLWLGYWAVQLNVCLSRIYLAAHFPHQVVAGVLSGIAVAETFSHIRGIYNASLQRYCLITFFLFGFALGFYLLLKGLGVDLLWTLEKAKRWCERPEWVHLDTTPFASLFKNLGTLLGLGLALNSSMYRKSCKGELRKSLPFRLACIVASLGLLHLFDSLKPPSQIESIFYILSFCKSATVPFASVSLIPYCLARLLGQTHKKSL
  
Inhibitor
Name:
BDBM50529620
Synonyms:
CHEMBL4558600
Type:
Small organic molecule
Emp. Form.:
C42H58O9
Mol. Mass.:
706.9045
SMILES:
[H][C@@]12CC[C@]3(C)[C@]([H])(CC=C4[C@]5([H])[C@](C)(O)[C@H](C)CC[C@@]5(CC[C@@]34C)C(O)=O)[C@@]1(C)C[C@@H](OC(C)=O)[C@H](OC(=O)\C=C\c1ccc(O)c(OC)c1)C2(C)C |r,t:9|
Structure:
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