Reaction Details Report a problem with these data
Target
Proteasome subunit beta type-9
Ligand
BDBM50526813
Substrate
n/a
Meas. Tech.
ChEMBL_1909309 (CHEMBL4411755)
IC50
415±n/a nM
Citation
Johnson, HWB; Lowe, E; Anderl, JL; Fan, A; Muchamuel, T; Bowers, S; Moebius, DC; Kirk, C; McMinn, DL Required Immunoproteasome Subunit Inhibition Profile for Anti-Inflammatory Efficacy and Clinical Candidate KZR-616 ((2 S,3 R)- N-(( S)-3-(Cyclopent-1-en-1-yl)-1-(( R)-2-methyloxiran-2-yl)-1-oxopropan-2-yl)-3-hydroxy-3-(4-methoxyphenyl)-2-(( S)-2-(2-morpholinoacetamido)propanamido)propenamide). J Med Chem 61:11127-11143 (2018) [PubMed] Article
More Info.:
Target
Name:
Proteasome subunit beta type-9
Synonyms:
3.4.25.1 | LMP-2d | Lmp2 | Low molecular mass protein 2 | Macropain chain 7 | Multicatalytic endopeptidase complex chain 7 | PSB9_MOUSE | Proteasome chain 7 | Proteasome subunit beta type-9 | Proteasome subunit beta-1i | Psmb9 | Really interesting new gene 12 protein | Ring12
Type:
PROTEIN
Mol. Mass.:
23390.72
Organism:
Mus musculus
Description:
ChEMBL_104441
Residue:
219
Sequence:
MLRAGAPTAGSFRTEEVHTGTTIMAVEFDGGVVVGSDSRVSAGTAVVNRVFDKLSPLHQRIFCALSGSAADAQAIADMAAYQLELHGLELEEPPLVLAAANVVKNISYKYREDLLAHLIVAGWDQREGGQVYGTMGGMLIRQPFTIGGSGSSYIYGYVDAAYKPGMTPEECRRFTTNAITLAMNRDGSSGGVIYLVTITAAGVDHRVILGDELPKFYDE