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Target
Proteasome subunit beta type-1
Ligand
BDBM50526813
Substrate
n/a
Meas. Tech.
ChEMBL_1909310 (CHEMBL4411756)
IC50
>250000±n/a nM
Citation
 Johnson, HWB; Lowe, E; Anderl, JL; Fan, A; Muchamuel, T; Bowers, S; Moebius, DC; Kirk, C; McMinn, DL Required Immunoproteasome Subunit Inhibition Profile for Anti-Inflammatory Efficacy and Clinical Candidate KZR-616 ((2 S,3 R)- N-(( S)-3-(Cyclopent-1-en-1-yl)-1-(( R)-2-methyloxiran-2-yl)-1-oxopropan-2-yl)-3-hydroxy-3-(4-methoxyphenyl)-2-(( S)-2-(2-morpholinoacetamido)propanamido)propenamide). J Med Chem 61:11127-11143 (2018) [PubMed]  Article
Target
Name:
Proteasome subunit beta type-1
Synonyms:
3.4.25.1 | Macropain subunit C5 | Multicatalytic endopeptidase complex subunit C5 | PSB1_MOUSE | Proteasome component C5 | Proteasome gamma chain | Proteasome subunit beta type-1 | Psmb1
Type:
PROTEIN
Mol. Mass.:
26375.40
Organism:
Mus musculus
Description:
ChEMBL_118871
Residue:
240
Sequence:
MLSTAAYRDVERELGMGPHGSAGPVQLRFSPYAFNGGTVLAIAGEDFSIVASDTRLSEGFSIHTRDSPKCYKLTDKTVIGCSGFHGDCLTLTKIIEARLKMYKHSNNKAMTTGAIAAMLSTILYSRRFFPYYVYNIIGGLDEEGKGAVYSFDPVGSYQRDSFKAGGSASAMLQPLLDNQVGFKNMQNVEHVPLTLDRAMRLVKDVFISAAERDVYTGDALRICIVTKEGIREETVPLRKD
  
Inhibitor
Name:
BDBM50526813
Synonyms:
CHEMBL4465456
Type:
Small organic molecule
Emp. Form.:
C35H48N4O5
Mol. Mass.:
604.7794
SMILES:
CC(C)C[C@H](NC(=O)CN1CCCCCC1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)[C@@]1(C)CO1 |r|
Structure:
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