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Target
Proteasome subunit beta type-8
Ligand
BDBM50526810
Substrate
n/a
Meas. Tech.
ChEMBL_1909307 (CHEMBL4411753)
IC50
110±n/a nM
Citation
 Johnson, HWB; Lowe, E; Anderl, JL; Fan, A; Muchamuel, T; Bowers, S; Moebius, DC; Kirk, C; McMinn, DL Required Immunoproteasome Subunit Inhibition Profile for Anti-Inflammatory Efficacy and Clinical Candidate KZR-616 ((2 S,3 R)- N-(( S)-3-(Cyclopent-1-en-1-yl)-1-(( R)-2-methyloxiran-2-yl)-1-oxopropan-2-yl)-3-hydroxy-3-(4-methoxyphenyl)-2-(( S)-2-(2-morpholinoacetamido)propanamido)propenamide). J Med Chem 61:11127-11143 (2018) [PubMed]  Article
Target
Name:
Proteasome subunit beta type-8
Synonyms:
Lmp7 | Low molecular mass protein 7 | Macropain subunit C13 | Mc13 | Multicatalytic endopeptidase complex subunit C13 | PSB8_MOUSE | Proteasome component C13 | Proteasome subunit beta type-8 | Proteasome subunit beta-5i | Psmb8
Type:
PROTEIN
Mol. Mass.:
30260.37
Organism:
Mus musculus
Description:
ChEMBL_104442
Residue:
276
Sequence:
MALLDLCGAARGQRPEWAALDAGSGGRSDPGHYSFSAQAPELALPRGMQPTAFLRSFGGDQERNVQIEMAHGTTTLAFKFQHGVIVAVDSRATAGSYISSLRMNKVIEINPYLLGTMSGCAADCQYWERLLAKECRLYYLRNGERISVSAASKLLSNMMLQYRGMGLSMGSMICGWDKKGPGLYYVDDNGTRLSGQMFSTGSGNTYAYGVMDSGYRQDLSPEEAYDLGRRAIAYATHRDNYSGGVVNMYHMKEDGWVKVESSDVSDLLYKYGEAAL
  
Inhibitor
Name:
BDBM50526810
Synonyms:
CHEMBL4443505
Type:
Small organic molecule
Emp. Form.:
C30H42N4O7
Mol. Mass.:
570.6771
SMILES:
COc1ccc(C[C@H](NC(=O)[C@H](C)NC(=O)CN2CCOCC2)C(=O)N[C@@H](CC2=CCCC2)C(=O)[C@@]2(C)CO2)cc1 |r,t:29|
Structure:
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