Reaction Details  Report a problem with these data
Target
Adenosine receptor A1
Ligand
BDBM50004589
Substrate
n/a
Meas. Tech.
ChEMBL_1913504 (CHEMBL4416087)
Ki
2.2±n/a nM
Citation
 Mallo-Abreu, A; Majellaro, M; Jespers, W; Azuaje, J; Caamaño, O; García-Mera, X; Brea, JM; Loza, MI; Gutiérrez-de-Terán, H; Sotelo, E Trifluorinated Pyrimidine-Based A J Med Chem 62:9315-9330 (2019) [PubMed]  Article
Target
Name:
Adenosine receptor A1
Synonyms:
A1 adenosine receptor (hA1) | A1AR | AA1R_HUMAN | ADENOSINE A1 | ADORA1 | Adenosine A1 receptor (A1AR) | Adenosine A1-receptor | Adenosine receptor A1 (A1) | Adenosine receptor A1 (hA1) | Adenosine transporter (AdT)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
36520.92
Organism:
Homo sapiens (Human)
Description:
P30542
Residue:
326
Sequence:
MPPSISAFQAAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTYFHTCLMVACPVLILTQSSILALLAIAVDRYLRVKIPLRYKMVVTPRRAAVAIAGCWILSFVVGLTPMFGWNNLSAVERAWAANGSMGEPVIKCEFEKVISMEYMVYFNFFVWVLPPLLLMVLIYLEVFYLIRKQLNKKVSASSGDPQKYYGKELKIAKSLALILFLFALSWLPLHILNCITLFCPSCHKPSILTYIAIFLTHGNSAMNPIVYAFRIQKFRVTFLKIWNDHFRCQPAPPIDEDLPEERPDD
  
Inhibitor
Name:
BDBM50004589
Synonyms:
8-Cyclopentyl-1,3-diethyl-3,7-dihydro-purine-2,6-dione | CHEMBL102859
Type:
Small organic molecule
Emp. Form.:
C14H20N4O2
Mol. Mass.:
276.3342
SMILES:
CCn1c2nc([nH]c2c(=O)n(CC)c1=O)C1CCCC1
Structure:
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