Target
Tyrosine-protein phosphatase non-receptor type 1
Ligand
BDBM50530825
Substrate
n/a
Meas. Tech.
ChEMBL_1913971 (CHEMBL4416554)
IC50
9800±n/a nM
Citation
 Zhou, JWu, ZOyawaluja, BOCoker, HABOdukoya, OAYao, GChe, CT Protein Tyrosine Phosphatase 1B Inhibitory Iridoids from  J Nat Prod 82:2916-2924 (2019) [PubMed]  Article
Target
Name:
Tyrosine-protein phosphatase non-receptor type 1
Synonyms:
PTN1_HUMAN | PTP1B | PTPN1 | Protein tyrosine phosphatase 1B (PTP1B) | Protein tyrosine phosphatase-1B (PTP1B) | Protein-tyrosine phosphatase 1B | Protein-tyrosine phosphatase 1B (PTP1B) | Tyrosine-protein phosphatase non-receptor type 1 | Tyrosine-protein phosphatase non-receptor type 1 (PTP1B)
Type:
Protein phosphatase
Mol. Mass.:
49963.76
Organism:
Homo sapiens (Human)
Description:
Human recombinant GST-fusion PTP1B (1-435).
Residue:
435
Sequence:
MEMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIMGDSSVQDQWKELSHEDLEPPPEHIPPPPRPPKRILEPHNGKCREFFPNHQWVKEETQEDKDCPIKEEKGSPLNAAPYGIESMSQDTEVRSRVVGGSLRGAQAASPAKGEPSLPEKDEDHALSYWKPFLVNMCVATVLTAGAYLCYRFLFNSNT
  
Inhibitor
Name:
BDBM50530825
Synonyms:
CHEMBL4582106
Type:
Small organic molecule
Emp. Form.:
C10H14O4
Mol. Mass.:
198.2158
SMILES:
[H][C@]12[C@H](O)CC(C)=C1COC(=O)[C@@H]2CO |r,c:6|
Structure:
Search PDB for entries with ligand similarity: