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Target
Polyamine deacetylase HDAC10
Ligand
BDBM50531480
Substrate
n/a
Meas. Tech.
ChEMBL_1920245 (CHEMBL4423090)
IC50
28±n/a nM
Citation
 Fernandes, GFDS; Fernandes, BC; Valente, V; Dos Santos, JL Recent advances in the discovery of small molecules targeting glioblastoma. Eur J Med Chem 164:8-26 (2019) [PubMed]  Article
Target
Name:
Polyamine deacetylase HDAC10
Synonyms:
3.5.1.98 | HD10 | HDA10_MOUSE | Hdac10 | Histone deacetylase 10
Type:
PROTEIN
Mol. Mass.:
72091.98
Organism:
Mus musculus
Description:
ChEMBL_116900
Residue:
666
Sequence:
MGTALVYHEDMTATRLLWDDPECEIECPERLTAALDGLRQRGLEERCLCLSACEASEEELGLVHSPEYIALVQKTQTLDKEELHALSKQYNAVYFHPDTFHCARLAAGAALQLVDAVLTGAVHNGLALVRPPGHHSQRAAANGFCVFNNVALAAKHAKQKYGLQRILIVDWDVHHGQGIQYIFNDDPSVLYFSWHRYEHGSFWPFLPESDADAVGQGQGQGFTVNLPWNQVGMGNADYLAAFLHVLLPLAFEFDPELVLVSAGFDSAIGDPEGQMQATPECFAHLTQLLQVLAGGRICAVLEGGYHLESLAQSVCMMVQTLLGDPTPPLLGLMVPCQSALESIQSVQTAQTPYWTSLQQNVAPVLSSSTHSPEERSLRLLGESPTCAVAEDSLSPLLDQLCLRPAPPICTAVASTVPGAALCLPPGVLHQEGSVLREETEAWARLHKSRFQDEDLATLGKILCLLDGIMDGQIRNAIATTTALATAATLDVLIQRCLARRAQRVLCVALGQLDRPLDLADDGRILWLNIRGKDAAIQSMFHFSTPLPQTTGGFLSLILGLVLPLAYGFQPDMVLMALGPAHGLQNAQAALLAAMLRSPVGGRILAVVEEESIRLLARSLAQALHGETPPSLGPFSKATPEEIQALMFLKARLEARWKLLQVAAPPP
  
Inhibitor
Name:
BDBM50531480
Synonyms:
CHEMBL4447524
Type:
Small organic molecule
Emp. Form.:
C24H24N4O5S
Mol. Mass.:
480.536
SMILES:
COc1ccc2n(CCCCCC(=O)NO)cc(C(=O)Nc3nc4ccccc4s3)c(=O)c2c1
Structure:
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