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Target
Prostaglandin G/H synthase 1
Ligand
BDBM50531489
Substrate
n/a
Meas. Tech.
ChEMBL_1920306 (CHEMBL4423151)
IC50
13000±n/a nM
Citation
 Pati, ML; Vitale, P; Ferorelli, S; Iaselli, M; Miciaccia, M; Boccarelli, A; Di Mauro, GD; Fortuna, CG; Souza Domingos, TF; Rodrigues Pereira da Silva, LC; de Pádula, M; Cabral, LM; Sathler, PC; Vacca, A; Scilimati, A; Perrone, MG Translational impact of novel widely pharmacological characterized mofezolac-derived COX-1 inhibitors combined with bortezomib on human multiple myeloma cell lines viability. Eur J Med Chem 164:59-76 (2019) [PubMed]  Article
Target
Name:
Prostaglandin G/H synthase 1
Synonyms:
COX1 | Cyclooxygenase-1 | Cyclooxygenase-1 (COX-1) | PGH1_SHEEP | PTGS1 | Prostaglandin G/H synthase (cyclooxygenase)
Type:
Protein
Mol. Mass.:
68868.60
Organism:
Ovis aries (Sheep)
Description:
n/a
Residue:
600
Sequence:
MSRQSISLRFPLLLLLLSPSPVFSADPGAPAPVNPCCYYPCQHQGICVRFGLDRYQCDCTRTGYSGPNCTIPEIWTWLRTTLRPSPSFIHFLLTHGRWLWDFVNATFIRDTLMRLVLTVRSNLIPSPPTYNIAHDYISWESFSNVSYYTRILPSVPRDCPTPMDTKGKKQLPDAEFLSRRFLLRRKFIPDPQSTNLMFAFFAQHFTHQFFKTSGKMGPGFTKALGHGVDLGHIYGDNLERQYQLRLFKDGKLKYQMLNGEVYPPSVEEAPVLMHYPRGIPPQSQMAVGQEVFGLLPGLMLYATIWLREHNRVCDLLKAEHPTWGDEQLFQTARLILIGETIKIVIEEYVQQLSGYFLQLKFDPELLFGAQFQYRNRIAMEFNQLYHWHPLMPDSFRVGPQDYSYEQFLFNTSMLVDYGVEALVDAFSRQPAGRIGGGRNIDHHILHVAVDVIKESRVLRLQPFNEYRKRFGMKPYTSFQELTGEKEMAAELEELYGDIDALEFYPGLLLEKCHPNSIFGESMIEMGAPFSLKGLLGNPICSPEYWKASTFGGEVGFNLVKTATLKKLVCLNTKTCPYVSFHVPDPRQEDRPGVERPPTEL
  
Inhibitor
Name:
BDBM50531489
Synonyms:
CHEMBL4445036
Type:
Small organic molecule
Emp. Form.:
C16H13FN2O2
Mol. Mass.:
284.285
SMILES:
COc1ccc(cc1)-c1c(N)onc1-c1ccc(F)cc1
Structure:
Search PDB for entries with ligand similarity: